ALOK BHATTACHARYA
Professor
School of Life Sciences
Jawaharlal Nehru University
New Delhi -110067, India
Room No.     : 117
Off. Phone    : 26704516
Residence    : 26136296
E-mail           :
alok0200@mail.jnu.ac.in , alok.bhattacharya@gmail.com

Education

M.Sc (chemistry) Indian Instititute of Technology, Kanpur; Ph.D. (life Sciences) Jawaharlal Nehru University, New Delhi

Current Position:

Professor, Jawaharlal Nehru University; Vice President, Indian National Science Academy

Awards and Honors:

Robert McNamara Fellow of the World Bank; S.S. Bhatnagar award; Fellow, Indian National Science Academy, New Delhi; J.C. Bose Fellowship

Research Interest:

  1. Phagocytosis plays a critical role in survival and pathogenesis of E. histolytica. It has been studied quite extensively in many mammalian systems, particularly in relation to the process of opsonization of pathogens. Unfortunately, the mechanisms are not at all understood in this parasite. Our major goal is to understand the molecular mechanisms at different stage of this process, particularly the initiation, propagation of the cup and then formation of phagosomes. We have identified a number of novel proteins, EhCaBP1, EhCaBP3 and EhC2PK that have been shown to participate in phagocytosis and actin dynamics.

  2. We are also investigating signaling systems that initiate proliferative response in E. histolytica and have identified a cell surface trans membrane kinase and unsaturated free fatty acids that are required for initiating signaling systems leading to proliferation.

  3. We develop tools and study genome evolution using comparative genomics. We have developed new algorithms for identifying genomic variations from both fully assembled genomes as well as from short read sequences derived from Next Generation of sequencing platforms. We have identified genomic mutational hot and cold spots from these data.

Selected Recent Publications:

  1. Shrimal S, Saha A, Bhattacharya S, Bhattacharya A. Lipids induce expression of serum-responsive transmembrane kinase EhTMKB1-9 in an early branching eukaryote Entamoeba histolytica. Sci Rep. 2012;2:333. Epub 2012 Mar 26. PubMed PMID:22451862; PubMed Central PMCID: PMC3312203

  2. Somlata, Bhattacharya, S., Bhattacharya, A. (2011) A C2 domain protein kinase initiates phagocytosis in the protozoan parasite Entamoeba histolytica. Nat. Commun. 2, 230, doi: 10.1038/ncomms1199

  3. Vaz C, Mer AS, Bhattacharya A, Ramaswamy R, 2011 MicroRNAs Modulate the Dynamics of the NF-?B Signaling Pathway. PLoS ONE 6(11): e27774. doi:10.1371/journal.pone.0027774

  4. Bharti R, Das R, Sharma P, Katoch K, Bhattacharya A (2011) MTCID: A database of genetic polymorphisms in clinical isolates of Mycobacterium tuberculosis. Tuberculosis (Edinb). 2012 Mar;92(2):166-72. Epub 2011 Dec 29

  5. Yadav VP, Mandal PK, Bhattacharya A, Bhattacharya S. Recombinant SINEs are formed at high frequency during induced retrotransposition in vivo. Nat Commun. 2012 May 22;3:854. doi: 10.1038/ncomms1855. PubMed PMID: 22617294.

  6. Somlata1, Sathisha K.3, Mridula Agrahari1, Mrigya Babuta1 Sudha Bhattacharya2 and Alok Bhattacharya (2012) Autophosphorylation of Ser428 of EhC2PK plays a critical role in regulating erythrophagocytosis in the parasite Entamoeba histolytica J. Biol. Chem. Vol. 287, Issue 14, 10844-10852, March 30, 2012

  7. Singh N, Ojha S, Bhattacharya A, Bhattacharya S. Stable transfection and continuous expression of heterologous genes in Entamoeba invadens. Mol Biochem Parasitol. 2012 Jul;184(1):9-12. Epub 2012 Mar 7. PubMed PMID: 22426570.

  8. Gupta R, Dewan Esha, Bharti Richa, Bhattacharya, A (2012) Differential expression analysis of RNA seq data. Article ID 817508, 8 pages
    doi:10.5402/2012/817508

  9. Aslam, S., Bhattacharya, S, Bhattacharya, A (2012) The Calmodulin-like calcium binding protein EhCaBP3 of Entamoeba histolytica regulates phagocytosis and is involved in actin dynamics. PLoS Pathogens (accepted)

  10. Das S, Duggal P, Roy R, Myneedu VP, Behera D, Prasad HK, Bhattacharya A. (2012) Identification of Hot and Cold spots in genome of Mycobacterium tuberculosis using Shewhart Control Charts. Sci Rep. (Nature) 2012;2:297. Epub 2012 Mar 2. PubMed PMID: 22389766; PubMed Central PMCID: PMC3291883

  11. Gupta AK, Panigrahi SK, Bhattacharya A, Bhattacharya S. Self-circularizing 5'-ETS RNAs accumulate along with unprocessed pre ribosomal RNAs ingrowth-stressed Entamoeba histolytica. Sci Rep. (Nature) 2012;2:303. Epub 2012 Mar 6.PubMed PMID: 22396851; PubMed Central PMCID: PMC3294279.

  12. Shrimal S, Saha A, Bhattacharya S, Bhattacharya A. Lipids induce expression of serum-responsive transmembrane kinase EhTMKB1-9 in an early branching eukaryote Entamoeba histolytica. Sci Rep. (Nature) 2012;2:333. Epub 2012 Mar 26. PubMed PMID:22451862; PubMed Central PMCID: PMC3312203

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