Dr. DEEPAK SHARMA

Associate Professor
School of Life Sciences
Jawaharlal Nehru University
New Delhi -110067, India.
Room No.      : 321
Off. Phone    : 26704508
Residence     : 25361769
E-mail
:
sharmadeepak@mail.jnu.ac.in    
 deepaksharma57in@yahoo.co.in

Education

M.Sc, Ph.D (1984) Kurukshetra University.

Career

1986-1991 Research Associate  School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067.
1991-1994 Pool Scientist (CSIR), School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067.
1996-2000 Research Associate, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067.
2000-Present Assistant Professor,   School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067.

Area of Research

Nutrition and Brain development
Neurobiology of Ageing and Mechanism of Action of Anti-ageing Drugs and plant products.     
                                        

Research Projects

  1. Anti-aging effects and mechanism of action of Exogenous Dehydoepiendrosterone (DEHA).Administration during normal aging in different brain regions, CSIR, 2002.

  2. Long Term effects of hormone therapy in Female Animals (as Co-PI), DBT, 2000.

Awards and Honour

III rd International Age Award 1989 by the International Gerontology Congress, Acapulco, Mexico.

Membership

  1. Indian Gerontology Association.

  2. International Brain Research Organization (IBRO).


Selected Publications

1. Sinha, N., Baquar, N.Z., and Sharma, D., (2005). Anti-lipidperoxidative role of exogenous Dehydro-epiendrsterone (DHEA) administration in normal ageing rat brain Indian J Exp. Biol. 43: 420-424.

2.  Moorthy, K., Yadava, U.C.S., Siddiqui, M.R., and Sharma, D., Basir, S.F., and Baquer, N.Z., (2004). Effect of estradiol and progesterone treatment on carbohydrate metabolizing enzymes in tissues of ageing female rats. Biogerontolgy, 5: 249-259.   

3.  Moorthy,K.,  Yadav, U.C.S., Mantha, A.K., Cowsik, S.M., Sharma, D., and Baquer, N.Z.,   (2004). Effect of    Estradiol and Progesterone Treatment on lipid profile in naturally menopausal rats from different age groups. Biogerontlogy 5: 1-9.

4.  Kaur J. Singh S. Sharma D Singh R (2003) Neuroprotective effects of l-deprenyl in the aging rat brain Biogerontology Vol 2(4) 105-111.

5.  Kaur J, Sharma D, Singh R (2001) Acetyl-l-carnitine enhances Na+,K+-ATPase  glutathione- S- transferase and multiple unit activity and reduces lipid peroxidation and lipofuscin concentration in aged rat brain regions. Neurosci Lett.  Mar; 301(1)1-4.

6.  Gopal PV. Sriram AV. Sharma D. Singh R (2000) Glutathione-S-transferase in the ageing rat brain cerebrum and the effect of chlorpromazine. Gerontology.  Jan-Feb; 46(1):7-11.

7. Sharma D. Maurya A. Singh R. (1993) Age-related decline in multiple unit action potentials of CA3 region of rat hippocampus: correlation with lipid peroxidation and lipofuscin concentration and the effect of centrophenoxine. NeurobiolAging.Jul-Aug; 14(4):319-30.

8. Rameshwar Singh, Deepak Sharma, (2006) Sangeeta Singh and Jaspreet Kaur Biochemical correlate of Electrophysiological Ageing of the Brain. In Pain: New Dimensions. Ed Prof. R Mathur. Pub. M/s Anamya Publishers (Invited) In Press.

9.  Rameshwar Singh and Deepak Sharma (2005) Electrophysiological Ageing of the Brain and pharmacology of Ageing. Cellular and Molecular Brain Ageing Ed Prof. MK Thakur Pub M/s Narosa Publishers.

10. K. Moorthy, Umesh C.S Yadav, Siddiqui M.R, Anil K. Mathur, Seema F. Basir, Sharma D, Sudha M. Cowsik and Najma Z Baquer (2005) Effect of hormone replacement therapy in normalizing age-related neuronal markers in different age groups of naturally menopausal rats. Biogerontology, Vol 6 (Accepted).

11. Sinha N, Baquer NZ and Sharma D (2005) Anti-lipidperoxidative role of exogenous                     Dehydroepiendrosterone (DHEA) administration in normal ageing rat brain. Indian J. Exp. Biol. 43:420-424.

12. Moorthy K, Sharma D, Basir SF and Baquer NZ (2005) Administration of estradiol and progesterone modulate the activities of antioxidant enzyme and aminotransferasees in naturally menopausal rats. Experimental Gerontol. 40:295-302.

13. Moorthy K, Umesh CS Yadava, Siddiqui MR, Sharma D, Basir SF and Baquer NZ    (2004) Effect of estradiol and progesterone treatment on carbohydrate  metabolizing enzymes in tissues of ageing female rats. Biogerontolgy 5(4): 249-259.  

14. Moorthy, Umesh C.S.Yadav, Mantha AK, Cowsik SM, Sharma D and Baquer NZ (2004) Estradiol and Progesterone Treatment on lipid profile in naturally menopausal rats from different age groups. Biogerontlogy 5(6): 411-419.

15. Kaur J. Singh S. Sharma D. Singh R. (2003) Aluminium-induced enhancement of Ageing-related parameters in rat brain regions. Indian J. Biochem.Biophys. 40:340-349.

16. Kaur J. Singh S. Sharma D Singh R (2003) Neuroprotective effects of l-deprenyl in the aging rat brain Biogerontology Vol 2(4) 105-111.

17.  Nupur Sinha and Deepak Sharma (2002) Antioxidative effects of exogenous administration of dehydroepiendrosterone (DHEA) in the ageing rat brain regions. Indian J. Physiology and Pharmacology (Suppliment) 46(5)60.

18. Kaur J, Sharma D, Singh R (2001) Acetyl-l-carnitine enhances Na+,K+-ATPase  glutathione- S- transferase and multiple unit activity and reduces lipid peroxidation and lipofuscin concentration in aged rat brain regions. Neurosci Lett.  Mar; 301(1)1-4.

19. Kaur J. Sharma D. Singh R. (1998) Regional effects of ageing on Na+, K (+)-ATPase activity in rat brain and correlation with multiple unit action potentials and lipid peroxidation. Indian J Biochem Biophys.Dec; 35(6):364-71.

20.  Sharma D. Singh R. (1996) Age-related decline in multiple unit action potentials of cerebral cortex correlates with the   number of lipofuscin-containing neurons.
Indian J Exp Biol.  Aug; 34(8):776-81.

21. Sharma D. Singh S (1995) Centrophenoxine activates acetylcholinesterase activity in hippocampus of aged rats. Indian J Exp Biol.  May; 33(5):365-8.

22.  Deepak Sharma and R.Singh  (1994)  Age-related changes in the number and histochemistry of lipofuscin containing neurons  and the effect of aging reversal drug Centrophenoxine on the senile neurons in the parietal cortex of rat.Ind.natn.sci.Acad.60B :523.

23. Deepak Sharma, R.Singh and A.K. Maurya  (1991) Response of age-related intra neuronal cytomorphological impairments in the cortical neurons to the Centrophenoxine in rats. Proc.Nat.Sci.Acad.India, 61 (2)

24. A.K. Maurya, Deepak Sharma and R.Singh (1989) Revival by Centrophenoxine of the electrophysiologic activity and multiple Unit Action Potentials of the CA3 areas of the hippocampus of the senile rats. In: Perspectives of aging research Ed by Prof GS Singhal & Rameshwar Singh Pub Narosa Press

25. Deepak Sharma (1987) Cytohistochemical techniques to assess the action of homeopethetic drugs in the nervous tissue with particular reference to lipofuscin stains. In journal Of Homeopathician Society of India. The Homeopathician. Pp 29.

26. Deepak Sharma (1990) Morphometric response of spinal cord ependymal cells to maternal protein deficiency during post-natal development in rats. Geobios.17 :( 2, 3): 131.

27. Deepak Sharma (1989) Cytochemical response of pyramidal neurons of lamina pyramidalis (Layer V) to protein malnutrition in the motor cortex of rat during post-natal development. Biologia. 35: (2).

28. Deepak Sharma (1989) Response of dimensional growth motor neurons during post-natal development of the spinal cord of white rat Rattus norvegicus. Biologia. 15: (2).

29. Deepak Sharma (1988) Protein malnutrition and dimensional growth of gray and white matter in the spinal cord of white rats Geobios.15: 188.

30. Deepak Sharma (1988) Cytochemical and cytomorphological response of cortical neurons on intra neuronal accumulation of an age pigment lipofuscin. .J Exp.Biol. 26: 400.

31. S.P.Sharma and Deepak Sharma (1986) On the post-natal development of the cervical spinal cord of young white rats: some histological observations. J.Exp.Biol. 5: (2).

32. Deepak Sharma and S.P. Sharma (1986) Effects of protein malnutrition on Lamina Multiformis (Layer V) of the somatosensory cortex of white albino rat Rattus norvegicus in terms of necleolar activity. Proc.Nat.Sci.Acad.India. 56 (b) ll: 111.

33. Deepak Sharma and S.P.Sharma (1986). The cytoarchetectural study on the motor cortex of the albino rat Rattus norvegicus. Biologia. 32 (I); 199.

34. S.P.Sharma and Deepak Sharma (1986) Effects of protein deficiency on the motor cortex of the white rats: A micrometric study. Adv.Bio.Sci. 5 (I): 33.

35. Deepak Sharma and S.P.Sharma (1986) Lipofuscin pigment in lamina V and Vl of the motor cortex of the 14 and 21 day old pups born to mothers induced to protein deficiency during pregnancy. Ind.J.Exp.Biol. 24:118.

36. S.P.Sharma and Deepak Sharma (1986) Effects of maternal protein malnutrition on the post-natal development of anterior horn cells of the offspring: A Cytohistochemical study. Pak.J.Zool. 18 (I): 99.

37. S.P.Sharma and Deepak Sharma (1985). Maternal protein deficiency and nucleolar volume: a micrometric study. Geobios. 12 (6): 259.

38. Deepak Sharma and S.P.Sharma (1985) Protein deficiency and post-natal development of the spinal cord of white rat, Rattus norvegicus: Histological and Histochemical study. U.P.J.Zool. 6 (2): 111.

39. Deepak Sharma and S.P.Sharma (1984). Effects of protein deficiency on the ependymal cells of the central canal in the cervical spinal cord of rat, Rattus norvegicus. J.Sci.Res. 5 (2): 95.

40. Deepak Sharma and S.P Sharma  (1983) Note on the measurement of motor neurons area in the spinal cord of the rat in terms of linear parameters at at ocular level. J.Sci.Res. 5 (I): 53.

41. S.P.Sharma and Deepak Sharma (1982) Cytoarchetectonic structure of the gray matter in the spinal cord of rat, Rattus norvegicus. Biologia. 28 (2):199.

42. Amar jyoti, Pallavi Sethi and Deepak Sharma (2007) Bacopa moneiera prevents from aluminium neurotoxicity in the cerebral cortex of rat brain. J. Ethanopharmacology 111:57-62

43. Kiran Bala, B.C Tripathy and Deepak Sharma (2006) Neuroprotective and anti-ageing effect of curcumin in aged rat brain regions. Biogerontology 7:81-89

44. Amar jyoti and Deepak Sharma (2006) Neuroprotective role of Bacopa monniera against aluminium-induced oxidative stress in the hippocampus of rat brain. Neurotoxicology 27:451-57

45. Moorthy K, Umesh C.S Yadav, Siddiqui M.R, Mantha Anil K, Basir Seemi F, Sharma D, Cowsik Sudha M and Baquer N.Z (2005) Effect of hormone replacement therapy in normalizing age-related neuronal markers in different age groups of naturally menopausal rats. Biogerontology 6 :1-11

46. Moorthy K, Sharma D, Basir SF and Baquer NZ (2005) Administration of estradiol and progesterone modulate the activities of antioxidant enzyme and aminotransferasees in naturally menopausal rats. Experimental Gerontol. 40 : 295-302

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