Special Centre for Molecular Medicine
Jawaharlal Nehru University
New Delhi 110 067, India.
Off. Phone : 26704559/26717544
Residence : 26711263
E mail : email@example.com
Dr. Mukhopadhyay received his PhD from Jadavpur University (Indian Institute of Chemical Biology), Calcutta and did his postdoctoral study in the laboratory of Biochemistry, NCI, NIH, USA.
Major focus of the laboratory is on the study of bacterial protein secretion system. The laboratory is also studying regulation of gene expression in pathogenic fungus as a collaborative project.
Helicobacter pylori type IV protein secretion system:
Helicobacter pylori are the major cause of chronic gastritis and play an important role in the pathogenesis of peptic ulcer, gastric adeno carcinoma and gastric lymphoma. Although half of the world’s population carries the highly diverse bacteria Helicobacter pylori, the clinical sequel develop in only a fraction of colonized individuals and most likely depend on differentially represented bacterial determinants and host characteristics.
Type IV secretion systems (TFSS) play an important role for the virulence of a number of pathogenic bacteria including H. pylori. TFSS are ancestrally related to the bacterial conjugation system and are thought to be versatile transporters of proteins and/or nucleic acids (effectors molecules) across the bacterial membrane to the extra cellular space or into eukaryotic target cells. Basic aim of this work is to understand the adaptation of TFSS to pathogen-host interactions using variety of biochemical, cell biological and molecular biological methods. In the long run the study may help to identify new target(s) for anti bacterial treatments.
Collaborative work: In ‘collaboration’ with Prof. Rajendra Prasad, we are recognizing polymorphism in the CDRI gene coding for drug efflux pump and regulation of its expression.
students awarded Ph. D.: 05