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HYALURONAN BINDING PROTEIN (HABP1): A NOVEL CELL SURFACE PROTEIN AND ITS FUNCTIONS:

  1. Prakash., Mansi, Kale., Smita, Ghosh., Ilora, Kundu., c. Gopal, and Datta., Kasturi, ‘Hyaluronan-binding protein 1 (HABP1/p32/gC1qR) induces melanoma cell migration 2 and tumor growth by NF-kappa B dependent MMP-2 activation through integrin 3 αvβ3 interaction’ J. Cell. Signal. 2011 May 6. [Epub ahead of print].
  2. Kumar., Vinod, Misor., M. Mohan, and Datta., Kasturi, "Simultaneous Accumulation of Hyaluronan Binding Protein 1 (HABP1/p32/gC1qR) and Apoptotic Induction of Germ Cells in Cryptorchid Testis" J.Androl.2011 Feb 10 [Epub ahead of print].
  3. Yadav., Gitanjali, Prasad L.A. Ramachandra., Bhakuni Vinod and Datta Kasturi., Competitive Inhibition of  S.pneumoniae Hyaluronidase by Hyaluronan Binding Protein1 (HABP1/p32/gC1qR), J. Biol. Chem. 284(6), 3897-3905 (2009).
  4. Chowdhury. A, Ghosh., I, Datta. K., Excessive reactive oxygen species induces apoptosis in fibroblasts: Role of mitochondrially accumulated hyaluronic acid binding protein 1 (HABP1/p32/gC1qR). Experimental Cell Research, 314, 651-667, (2008).
  5. Hyaluronan Binding Protein 1 (HABP1/p32/gC1qR): A New Perspective in Tumor Development in Cancer cell, Anindya Roy Chowdhury, Anupama Kamal, Ilora Ghosh and Kasturi Datta. In Cancer Biology edited by Robert Stern (2008).
  6. Biswas, Anup., Hafiz Abdul, Banerjee Bhaswati, Kim S. Kwang, Datta. K., and Chitnis D. Chetan. Plasmodium falciparum Uses gC1qR/HABP1/p32 as a Receptor to Bind to Vascular Endothelium and for Platelet-mediated Clumping. PLoS Pathogens. 3(9)1271-1280, (2007).
  7. Ghosh, I., Chattopadhaya, Ratna., Vinod Kumar, Chakravarty, B.N., and Datta. K. Hyaluronan binding protein-1: a modulator of sperm-oocyte interaction. Gamete Biology Emerging Frontiers in Fertility and Contraceptive Development. Page No.539-543 (2007).
  8. Sonu Chand Thakur and Datta. K. Higher Expression of Hyaluronan Binding Protein1 (HABP1/p32/gC1qR/SF2) during Follicular Development and Cumulus Oocyte Complex Maturation in rat”. Molecular Reproduction and Development. 9999, 1-10 (2007).
  9. Thakur., S.C., Kumar. V., Ghosh. I., Bharadwaj, A., Datta. K., Appearance of Hyaluronan Binding Protein 1 Proprotein in Pachytene Spermatocytes and Round Spermatids Correlates with Spermatogenesis. J. Andrology, 27(4):604-610, 2006.
  10. Anupama and K. Datta, Upregulation of Hyaluronan Binding Protein1 (HABP1/p32/gC1qR) is associated with Cisplatin induced Apoptosis. Apoptosis, 11(5):861-74, 2006.
  11. Mallick, J. and Datta, K. HABP1/p32/gC1qR induces aberrant groth and morphology in Schizosaccharomyces pombe through its N-terminal a helix. Exp. Cell Res. 309 (2005) 250-263.
  12. Sengupta, A., Banerjee, B., Tyagi, R.K. and Datta, K. Golgi localization and dynamics of Hyaluronan Binding Protein 1 (HABP1) during interphase and mitotic stages Cell Research 15(3), 183-186. (2005).
  13. Ghosh, I., Chowdhury, A.R., Rajeswari, M.R. and Datta, K. Differential expression of Hyaluronan binding protein 1 during progression of epidermal carcinoma. Mol. Cell. Biochem. 267(1-2), 133-139 (2004).
  14. Jha, B.K., Mitra, N., Rana, R., Surolia, A., Salunke, D.M. and Datta, K. pH and cation induced thermodynamic stability of human Hyaluronan binding protein 1 regulates its hyaluronan affinity. J. Biol. Chem. 279 (22), 23061-23072 (2004).
  15. Sengupta, A., Tyagi, R.K. and Datta, K. Truncated variants of hyaluronan binding protein 1 bind hyaluronan and induce identical morphological aberrations in COS-1 cells. Biochem J. 380, 837-844 (2004).
  16. Aniruddha Sengupta, Ilora Ghosh, Jaideep Mallick, Ashoke Ranjan Thakur and Kasturi Datta. Presence of a human Hyaluronan Binding Protein 1 (HABP1) pseudogene like sequence in Methanosarcina barkeri suggests its linkage in evolution. DNA and Cell Biology. 23(5), 301-310 (2004).
  17. Meenakshi J, Sengupta A, Ghosh I, Chowdhury AR, Mallick J, Anupama and Datta K. Growth Inhibition and Apoptosis Induction by constitutive expression of Hyaluronic acid Binding protein1 in Normal Fibroblast and Cos-1 Cells. Accepted in Proceedings of HA-2003. Chapter 4: Hyaluronan & Tumor, Volume 1, Hyaluronan page 349-359.
  18. Jha, B.K., Salunke, D.M. and Datta, K. Structural flexibility of multifunctional HABP1 may be important for its binding to different ligand. J. Biol. Chem. 278(30), 27464-27472 (2003).
  19. Meenakshi, J., Anupama, Goswami, S.K. and Datta, K. Constitutive expression of Hyaluronan Binding Protein 1 (HABP1/p32/gC1qR) in normal fibroblast cells perturbs its growth characteristics and induces apoptosis. Biochem. Biophys. Res. Commun. 300(3), 686-693 (2003).
  20. Ghosh, I. and Datta, K. Sperm surface hyaluronan binding protein (HABP11) interacts with zona pellucida of water buffalo (bubalus bubalis) through its clustered mannose residues. Mol. Rep. Dev. 64(2), 235-244 (2003).
  21. Jha, B.K., Salunke, D.M. and Datta, K. Central Role of Hyaluronan in Regulating the Functions of Multilig and Binding Human Hyaluronan Binding Protein 1 (HABP1). Proceedings on “Hyaluronan 2003”. Vol.I, page 35-41.
  22. J. Meenakshi, A. Sengupta, I. Ghosh, A.R. Chowdhury, J. Mallick, Anupama and Datta. K., Growth Inhibition and Apoptosis Induction by Constitutive Expression of Hyaluronan Binding Protein1 (HABP1) in Normal Fibroblast and COS-1 Cells. Vol.I. Page 349-359
  23. Majumdar, M., Bharadwaj, A., Ghosh, I., Ramachandran, S. and Datta, K. Evidence for the presence of HABP1pseudogene in multiple locations of mammalian genome. DNA & Cell Biology 21(10), 727-735 (2002).
  24. Majumdar, M., Meenakshi, J., Goswami, S.K. and Datta, K. Hyaluronan binding protein 1 (HABP1)/C1QBP/p32 is an endogenous substrate for MAP Kinase and is translocated to the nucleus upon mitogenic stimulation. Biochem. Biophys. Res. Commun.291, 829-837 (2002).
  25. Jha, B.K. Salunke, D.M. and Datta, K. Disulfide bond formation through Cysteine186 facilitates functionally relevant dimerization of trimeric Hyaluronan Binding Protein 1 (HABP1)/p32/gC1qR Eur. J. Biochem. 269, 298-307 (2002).
  26. Archana Bharadwaj, Ilora Ghosh, Aniruddha Sengupta, Trevor  G. Cooper, Gerhard F. Weinbauer, Martin H. Brinkworth, Eberhard Nieschlag and K. Datta. Stage specific expression of proprotein form of hyaluronan binding protein 1 (HABP1) during spermatogenesis in rat. Mol Reprod Dev.; 62(2):223-232, (2002).
  27. Ilora Ghosh, Archana Bharadwaj and K. Datta. Reduction in the level of hyaluronan binding protein 1 (HABP1) is associated with loss of sperm motility. Am. J. Reprod. Immunol. 53(1-2), 45-54, (2001).
  28. Rajeev Kumar, Nirupam R. Choudhary, Dinakar M. Salunke and K. Datta. Evidence for clustered mannose as a new ligand for hyaluronan-binding protein (HABP1) from human fibroblast. J. Biosci. 26(3): 325-332, (2001).
  29. Ghosh, I. and Datta, K. A process for detection of male infertility using the kit for identifying the percentage of motile sperms. (Patent C.B.R. 3750 dated 29/3/2001).
  30. T.B. Deb, M. Majumdar, A. Bharadwaj, B.K. Jha and K. Datta. An insight into cellular signalling mediated by Hyaluronan binding protein (HABP1). Hyaluronan Volume I, Eds. J F Kennedy, G.O. Phillips and P.A. Williams Woodhead Publishing Limited (2001), pp 365-372.
  31. HABP1 as synonyms of C1QBP Genecard. GDBID: 373424.
  32. Ch. Mastan Rao, Poonam Salotra and K. Datta. Possible role of the 34 kDa hyaluronic acid binding protein in visceral leishmaniasis. J. Parasitology 85, 682-687, (1999).
  33. Mithu Majumdar and K. Datta. Assignment of cDNA encoding hyaluronic acid binding protein 1 to human chromosome 17 p12-13. Genomics. 51, 476-477 (1998).
  34. Ch. Mastan Rao, Tushar Baran Deb, Sanjay Gupta and K. Datta. Regulation of cellular phosphorylation of hyaluronan binding protein and its role in the formation of second messenger. Biochimica et Biphysica Acta 1336, 387-393, (1997).
  35. Satarupa Das, Tushar Baran Deb, Rajeev Kumar and K. Datta. Multifunctional activities of human fibroblast 34-kDa hyaluronic acid-binding protein. Gene 190, 223-225, (1997).
  36. Deb, Tushar and  Datta, K. Molecular cloning of human fibroblast hyaluronic acid binding protein confirms its identify with P-32, A protein copurified with  splicing factor SF2. J. Biol. Chem. 269, 2206-2212, (1996).
  37. Ch. Mastan Rao, Tushar Baran Deb and K. Datta. Hyaluronic acid induced hyaluronic acid binding protein phosphorylation and inositol triphosphate formation in lymphocytes. Biochemistry and Molecular Biology International. 40, 327-337, (1996).
  38. Ch. Mastan Rao, Arshad Jilani, Snehasikta Swarnakar, Tushar Baran Deb and K. Datta. A method to radio-iodinate hyaluronic acid and its use as a probe to detect hyaluronic acid binding proteins. Anal. Biochem. 236, 171-173, (1996).
  39. Ranganathan, S., Bharadwaj, A. and Datta, K. Hyaluronan mediates sperm motility by enhancing phosphorylation of proteins including hyaluronan binding protein. Cellular and Molecular Biology Research. 41(5), 467-476, (1995).
  40. Ranganathan, S. and Datta, K. Presence of hyaluronan binding protein in cardiac myoblasts and its altered level during myogenesis Cell Biology Internation 19, 161-165, (1995).
  41. Ranganathan,  S.,  Ganguly, A.K and Datta, K. Evidence  for presence of hyaluronan binding protein on spermatozoa and its possible  involvement in sperm function. Molecular Reproduction and Development. 38, 69-76, (1994).
  42. Tyagi, R.K. and Datta, K. In vitro translocation of Alanine: dioxovalerate transaminase into rat kidney mitochondria. J. Biochem. 113: 557-562, (1993).
  43. Gupta, S., Deb, T.B and  Datta, K. Evidence for the existence of  hyaluronectin-binding in the plasma membranes. FEBS Lett. 336, 511-515, (1993).
  44. Babu, B.R., Gupta, S. and  Datta,  K. Evidence for autophosphorylation of hyaluronate binding  protein  and its enhanced  phosphorylation in rat histiocytoma. Biochem. Biophys. Res. Commun. 177(3), 1291-1298, (1991).
  45. Gupta, S. and Datta, K.  Possible role of hyaluronectin on cell adhesion in rat histiocytoma. Expt. Cell Res. 195(2), 386-394, (1991).
  46. Gupta,  S., Babu, B.R., and Datta, K. Purification,  partial characterization  of  rat  kidney  hyaluronic  acid  binding protein and  its  localization on the cell surface. Eur. J. Cell  Biol. 56 (1) 58-67, (1991).
  47. Babu,  B.R.,  Gupta, S. and Datta, K.   Elevated level of hyaluronic  acid binding protein in diabetic rats. Biochem. Int. 22, 877-886, (1990).
  48. D'Souza,  M.  and Datta, K.  Studies  on  the  affinity  of hyaluronic acid binding protein to glycosaminoglycans. Biochem. Int. 13, 88-90, (1987).
  49. D'Souza, M. and Datta, K.  A novel glycoprotein that  binds to  hyaluronic acid. Biochem. Int. 13, 79-88, (1986).
  50. D'Souza, M. and Datta, K.  A evidence for naturally occurring hyaluronic acid binding protein in liver. Biochem. Int. 10, 43-51, (1985).

CELL DIFFERENTIATION: ENVIRONMENTAL CONTROL AND GENE EXPRESSION

  1. Datta, K.  Restricted expression of myosin light chain in mucular dystrophy. Biochemistry Int. 23, 193-201, (1991).
  2. Siddiqui, M.A.Q., Danishefsky, K., Gabot, M., Datta, K.  and Mendola, C. Structural and functional analysis of regulatory sequences  in  heart  myosin light chain 2 gene promoter  in `Mechanism  of control of gene expression' Edt. by  A.M. Skalka, Siddiqui, M.A.Q. and Weissbach, H. (1987).
  3. Danishefsky, K., Datta, K. and Siddiqui, M.A.Q.   Regulation of  embryonic  muscle gene expression. Fed. Proceeding. 46, 514, (1987).
  4. Arnold, H.H., Dombey, H., Datta, K., and  Siddiqui,  M.A.Q. Clonning partial sequencing and expression of glyceralldehyde 3-phosphate dehydrogenase  gene in chick embryonic  heart  muscle cells.  J. Biol. Chem. 257, 9827, (1982).
  5. Jakowlew, S.B., Khandekar,  P., Datta, K., Arnold, H.H.  and Siddiqui,  M.A.Q. Molecular  cloning  and  expression  of cardiac specific  myosin  heavy chain gene sequence in chick embryo.  J. Mol. Biol. 156, 637, (1982).
  6. Ahmed, A., Datta, K., Jakowlew, S.F. and  Siddiqui,  M.A.Q. Analysis of cardiac muscle gene transcription in early chick embryonic  development.  Proc. The Third Cleveland Symposium  on Macromolecules recombinant DNA, Cleveland  (1981).
  7. Ahmed, A., Datta, K., Jakowlew, S.F. and  Siddiqui,  M.A.Q. Control  of  cardiac muscle gene expression  in  early embryonic development. Fed. Proc. 40, 1627, (1981).
  8. Bhatia, B., Datta, K. and Nijhawan, R. Hypoxic Tolerance of rats with isoproterenol-induced myocardial necrosis. Advances in Myocardiology 2, (1980)
  9. Datta, K.  Myogenesis of cultured heart cell in presence of food antioxidants. J. Mol. and Cell Cardiology. 12, (1980).
  10. Datta,  K.  In vitro studies on heart cell  biogenesis.  J. Mol. and Cell Cardiology. 10, 20, (1978).
  11. Harary, I., Datta, K. and Hoover, F.  In vitro  studies  of beating  heart cells in culture XVI. The effect of a heat stable serum  fraction  on the level of myosin  ATPase.  Arch.  Biochem. Biophys. 156, 573-580, (1973).

ENVIRONMENTAL TOXICOLOGY AND HEME BIOSYNTHESIS

  1. Sagar, R., Salotra, P., Bhatnagar, R. and Datta, K. L. Alanine 4,5-dioxovalerate transaminase in Leishmania donovani that differs from mammalian enzyme. Microbiol. Res. 150, 419-423, (1995).
  2. Rakesh Kumar Tyagi and K. Datta.  A rapid, High-yield purification of L-alanine: 4,5-dioxovalerate transaminase from rat kidney mitochondria using an improved enzyme assay method.  Protein Expression and Purification 5, 527-533, (1994).
  3. Tyagi,  R.K.  and  Datta, K.   In  vitro  translocation  of Acanine: dioxovalerate transaminase into rat kidney mitochondria. J. Biochem. 113, 557-562, (1993).
  4. Singh,  N.K.,  Tyagi, R.K. and Datta,  K.  Cytosolic  L-alanine: 4,5-dioxovalerate transaminase  differs from  the mitochondrial form Eur. J. Biochem. 198, 581-587, (1991).
  5. Tyagi, R.K. and Datta, K.  Localization of L-alanine: 4,5-dioxovalerate  transaminase  in  the matrix  of the  rat kidney mitochondria. Biochem. Int. 33, 999-1006, (1991).
  6. Hoare, K. and Datta, K.  Characteristic of L-alanine: 4,5-dioxovalerate   transaminase   an  alternate  pathway of heme biosynthesis in yeast. Arch. Biochem. Biophys. 275, (1990). 
  7. Prasad, A.R.K. and Datta, K.  Synergistic effect of  allyl isopropyl acetamide with cadmium on hepatic heme biosynthesis  in chick embryo. Indian J. Med. Res. 90, 367-371, (1989).
  8. Prasad, D.D.K., Singh, N.K., Prasad,  A.R.K. and Datta, K. and Purification  and   properties  of  ALA   dehydratase  from Bajra seedings. Biochemistry Int. 17, 87-102, (1988).
  9. Singh,  N.K.,  Chhabra, R.  and  Datta,  K.   Non-enzymatic synthesis  of aminolevulinate (ALA) by cobalt. Biochem.  Biophys. Res. Commun. 143, 439-446, (1987).
  10. Shanker, J. and Datta, K. Excess generation of heme inhibits L-alanine: 4,5-dioxovalerate transaminase in  rat liver mitochondria. Biochem. Biophys. Res. Commun., 138, 751-757, (1986).
  11. Chhabra, R., Singh, N.K. and Datta, K. Induction of L-alanine: 4,5-dioxovalerate transaminase by phenylhydrazine is associated with depletion of heme level. Biochem. Biophys. Res. Commun. 138, 742-750, (1986).
  12. Shanker,  J.  and  Datta,  K.   Affinity  purification  and properties   of   rat   liver   mitochondrial   L-alanine: DOVA transaminase and its inhibition by hemin. Arch. Biophys. Biochem. 248, 652-657, (1986).
  13. Dalwani,  R.R., Dave, J.M. and Datta, K. Alterations  in hepatic  heme  metabolism in fish exposed  to  sublethal cadmium level. Biochem. Int. 10, 32-42, (1985).
  14. Shanker,  J.  and Datta, K.  Evidence of hemin  as  an  end product inhibitor of L-alanine: 4,5-dioxovalerate transaminase in rat liver mitochondria. FEBS Letter. 189, 129-132, (1985).
  15. Singh, N.K. and Datta, K. Purification and  characterization of rat kidney alanine dioxovalerate transaminase and inhibition by hemin. Biochem. Biophys. Acta. 827, 305-309, (1985).
  16. Shanker, J., Prasad,  A.R.K. and Datta, K.  Embryo  toxicity of styrene  and its effect on heme biosynthesis. Ind.  J. Expt. Biol. 22, 167, (1984).
  17. Prasad, A.R.K. and Datta, K.  Altered regulation of  hepatic heme metabolism in cadmium exposed chick embryo. Biochem. Intern. 8, 289, (1984).
  18. Prasad,  A.R.K.  and  Datta, K. Evidence  for  an  inducible  cadmium binding protein metallothionein in chick embryo. Biochem. Intern. 7, 677, (1983).
  19. Shanker, J. and  Datta, K.  Purification and  properties of alanine dioxovaleric acid   transaminase from   rat liver mitochondria. Biochem. Intern. 7, 23, (1983).
  20. Shanker, J. and Datta, K.  Effect of exposure to chick embryo on aminolevulinic acid metabolism. Ind. J. Biochem. Biophys. 18, 160, (1981).
  21. Prasad,  A.R.K. and  Datta, K.  Altered  regulation  of  ALA metabolism  in  cadmium   exposed  chick  embryo.   Ind.  J. Biochem. Biophys. 18, 167, (1981).
  22. Prasad, A.R.K. and Datta, K.  Induction of metallothinein in cadmium  treated chick embryo. Ind. J. Biochem. Biophys. 17, 114, (1980).
  23. Bhatia,  B. and  Datta, K. Hypoxic tolerance  of  rats  with isopreternal induced myocardial necrosis.  Advance in Myocardial 2, 101, (1979).
  24. Bhatia, B. and Datta, K.and Nijhavan, R.  Hopoxic  tolerance of rats with myocardial necrosis. J. Mol. and Cell cardiology 10, 8, (1978).
  25. Datta, K. and  Ghosh, J.J.  Hepatic induction  od  threonine dehydrase   and  tryptophan  pyrrolase  in  tyrosine  fed rats. Experimentia 38, 1018, (1977).
  26. Datta,  K.  and  Ghosh, J.J.  Effect  of  dietary  threonine  supplementation  on tyrosine toxicity in the rats.  J. Nutrition 107, 1675, (1977).
  27. Datta,  K.  and  Wajda,   I.J. Morphine-induced   kinetic alteration   of  cholineacetyltransferase  of  the  rat caudate nucleus. Brit. J. Pharm. 14, 732-739, (1971).
  28. Wajda,  I.J. and Datta, K. Effect of drugs on  acetylcholine metabolism  in the caudate nucleus of rats.  Pharmacologist. 13, 677, (1971).
  29. Datta, K., Tal. L. and Wajda, I.J. The effects of morphine on  cholineacetyltransferase  levels in caudate  nucleus  of  the rats. Brit. J. Pharm. 41, 84-93, (1971).
  30. Wajda, K., Tal, L. and Datta, K.  Kinetic studies of choline acetyl transferase obtained from caudate nucleus of rats treated with morphine. Fed. Proc. 29, 685, (1970).
  31. Datta,  K.  and  Wajda, I.J.  The  effect  of  morphine  and acetylcholine on brain choline acetyltransferase on rats. Pharmacologist 12, 211, (1970).

TECHNIQUES

  1. Tyagi, R.K., Babu, B.R., and Datta, K. Simultaneous determination of native and subunit molecular weights of proteins by  pore  limit  electrophoresis and  restricted use  of  sodium dodecyl sulfate.  Electrophoresis 14, 826-828 (1993).
  2. Tyagi, R.K. and Datta, K. A process for the preparation  of acidic Henna leaf extract useful for detection of proteins. Patent-(C.B.R.7694/Del/92 dated 7.10.92).
  3. Rakesh Kumar Tyagi, Richa Sagar and Kasturi Datta. A sensitive method for detection of protein in polyacrylamide gels and on protein blots using acidic henna leaf extract. Biotechnology Techniques 8, 583-588, (1994).
  4. Sagar R., Tyagi R.K. and Datta, K. A process for preparation of highly sensitive stain for protein detection in Western blot and polyacrylamide gel from dried henna leaf powder. Patent 769/DEL/94/293, (1994)
  5. Ilora Ghosh and K. Datta. A process for preparation of male infertility using the kit for identifying the percentage of motile sperm. Is under process for the patent of Govt. of India. Indian Patent No. 194645 Granted on February 17, 2006 Application No.378/DEL/2001 filed on 29/03/01 by Govt. of India.
  6. Ilora Ghosh and K. Datta. In vitro fertilization promoter. Is under process for the patent of Govt. of India. Patent Application No. 1289/DEL/2002 dated 20th December 2002.