Dr. Rohini Muthuswami

WELCOME TO THE CHROMATIN REMODELING LABORATORY (CRL)

JNU	SLS	CRL	RESEARCH	PEOPLE	COURSES	CONTACT
Exploring the role of SMARCAL1: What does SMARCAL1 do in the cell? It is curious because the protein is not present in the yeast. The protein is also classified as a distant member of the SWI/SNF proteins. We use cell biology tools to understand the role of SMARCAL1 in the mammalian cell. The protein is present in the cytoplasm and moves into the nucleus only when needed. This is a neat way of regulating the function of the protein. The protein co-localizes with b-tubulin during mitosis. Downregulation causes spindle defect, delayed cell cycle, and induces apoptosis. Interestingly, SMARCAL1 co-localizes with gH2AX at the apoptotic ring. We are now asking: How is SMARCAL1 regulated? Why does it co-localize with b-tubulin during mitosis? What are the other roles of SMARCAL1 in the cell?

WELCOME TO THE
CHROMATIN REMODELING LABORATORY (CRL)

JNU

Exploring the role of SMARCAL1:

What does SMARCAL1 do in the cell? It is curious because the protein is not present in the yeast. The protein is also classified as a distant member of the SWI/SNF proteins.

We use cell biology tools to understand the role of SMARCAL1 in the mammalian cell. The protein is present in the cytoplasm and moves into the nucleus only when needed. This is a neat way of regulating the function of the protein.

The protein co-localizes with b-tubulin during mitosis. Downregulation causes spindle defect, delayed cell cycle, and induces apoptosis. Interestingly, SMARCAL1 co-localizes with gH2AX at the apoptotic ring.

We are now asking:

How is SMARCAL1 regulated?

Why does it co-localize with b-tubulin during mitosis?

What are the other roles of SMARCAL1 in the cell?