PROF.SUDHA M COWSIK

Professor
School of Life Sciences
Jawaharlal Nehru University
New Delhi -110067, India.
Room No.      : 304
Off. Phone    : 26704517
Residence     : 26177359
E-mail           : scowsik@mail.jnu.ac.in

 

Education

Ph.D                     All India Instiutute of Medical Sciences (AIIMS), Delhi, India, 1976.
Post MSc (Dip)       Indian Institute of Technology (IIT), Delhi, India, 1971.
MSc (Hons. Sch)    Punjab University, Chandigarh, India, 1970.
BSc (Hons. Sch)    Punjab University, Chandigarh, India1969.

Career

July 76- Dec 76        Post Doctoral Research Fellow,AIIMS, Biophysics Department.
Jan 77- Dec 78         Pool Officer (CSIR) AIIMS, Delhi, Centre for Biomedical Engineering.
Jan79-April 85          Assistant Professor, IIT and AIIMS, Delhi, Centre for Bio-Medical Engineering.
May 85-Aug 95         Associate Professor, School of Life Sciences, Jawaharlal Nehru University, New Delhi.
Sep. 95 till date          Professor,School of Life Sciences, Jawaharlal Nehru University,New Delhi.

Area of Research

Structural Biology, Bioinformatics.
Structure and dynamics of neuropeptides employing information technology.

Research Projects

  1. Principal   Investigator- Molecular dynamics and spectroscopic characterisation of      cyanobacterial phycobiliproteins, Department. of Biotechnology, Government  of  India,2003-2006. Rs. 16, 00,000.

  2. Principal   Investigator -Structure based drug design:  Structural characterization of tachykinin -G protein coupled receptor complex, Department. of Science and Technology, Government  of  India , 2003-2006.

  3. Principal   Investigator-   Tachykinin neuropeptides,Neurokinin B and   Eledoisin:A molecular modelling,NMR and other spectroscopic investigation,, Council  of Scientific  and Industrial Research,  Government  of  India, 2003-2006.

  4. Principal Investigator - The Role of Tachykinin  Neuropeptides on Molecular and Biochemical Correlates in Aging Brain Functions, Excellence Programme, University Grants Commission,India,2002-2007, Principal Investigator -  Lipid induced Structure of Neuropeptide  Gamma and its analogues-A molecular modeling, Molecular Dynamics and NMR spectroscopic investigation, University Grants Commission, India, 2002-2005.

 Awards and Honour

  1. National Merit Scholarship holder throughout academic career.

  2. S.V. Talekar Memorial Award, AIIMS, Delhi 1981.  

  3. Member, National Academy of Sciences, India, 2002.

  4. Visiting Scientist, Albert Einstein College of Medicine, New York with Dr Gene Morril & Dr R.Gupta May, 83-July83.          

  5. Visiting Scientist under INSA- JSPS Exchange Programme, National Cancer Research Institute, Tokyo, with Dr H Saito, Jan84-March84.           

  6. Max Planck fellow, Max Plank Institute, Gottingen, Germany, with Prof. H. Kuhn ,  April84-July84.                                      

  7. High level fellowship exchange scientist, University of Louis Pasteur, Strasbourg, France with Prof. R. Cerf, May85-Aug85.           

  8. Visiting Scientist, TWAS-Chinese Academy of Sciences, Changchun Institute of Physics, China, with Prof. Zhang Xinyi, May89-July89.            

  9. Fulbright Scholar, US Department of Agriculture Plant Molecular Biology Lab, Beltsville, Maryland,USA  with Dr. Autar K. Mattoo,  Dec89-March90.         

  10. Visiting Scientist,   INSA-DFG Exchange Programme, Goethe University Franfurt, Germany with Prof. H. Ruterjans, Dec91-Dec92.             

  11. JNC Fellow, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, Aug94-Dec95.           

  12. Homi Bhabha Fellow, Indian Institute of Science Bangalore, Jan.96-Dec.98. 

Selected Publications

i) Book

Trends in Biomedical Engineering, S.K. Guha, Sneh Anand and Sudha Mahajan, pp. 357, CBME Publication, 1978.

ii) Ph.D. Thesis

Submolecular Mechanisms in Drug Action - A Topographical Analysis of TricyclicAntidepressants, All India Institute of Medical Sciences, New Delhi 1976.

iii) Publication in Peer reviewed International Journals

  1. Sudha Mahajan, K. Sundaram and R.K.Mishra, ‘A note on steric correspondence between tricyclic antidepressants and   Serotonin' Physiol. Chem. and Physics, 6, 537-540 (1974).

  2. K. Sundaram, Sudha Mahajan and R.K. Mishra, `A quantitative approach to the comparison of biomolecular topographies’ Physiol. Chem. and Physics, 6, 469-78 (1974).

  3. K.Sundaram and Sudha Mahajan, 'Characterization of norepine-phrine   channel in adrenergic nerve cell membrane' in Biophysical and   Biochemical   Information Transfer in Recognition Eds. J.G. Vassileva-Popva and E.V.Jansen, 1979, Plenum Press.        

  4. K.Sundaram and Sudha Mahajan, `Theoretical studies on tricyclic antidepressants-1 Molecular Structure’, Physiol Chem. and Phys, 13, 183-192 (1980).

  5. K.Sundaram and Sudha Mahajan, `Theoretical studies on tricyclic   antidepressants-II'   Electronic    Structure' on tricyclic Nuclic and Biogenic Amines.   Physiol Chem.  And Phys, 13, 313-325 (1981).

  6. K. Sundaram and Sudha Mahajan, `Theoretical studies on tricyclic antidepressants-III', Analysis of Stereospecificity’, Physiol Chem. and Phys, 13, 387-397 (1981).

  7. Sudha Mahajan and K.Sundaram, `Theoretical studies on tricyclic antidepressants-IV Probable Submolecular Topographic Structure of the Amine Pump Receptor',Physiol  Chem. and Phys, 13, 523-526 (1981).

  8. M.M. Misro, S.K. Guha, Harpal Singh, Sudha Mahajan, A.R. Ray and   P   Vasudevan,    `Injectable   Noncclusive   Chemical Contraception in the male-I'  Contraception, 20, 5,  467-474 (1981).

  9. M.M. Misro, S.K. Guha, Sudha Mahajan and K. Verma,`InjectableNonocclusive  Chemical Contraception in  the  Male-III.Biocompatibility  and  SEM  Studies',   Indian  J.   Physiol. Pharmacol., 24, 5, 435 (1980).

  10. Sudha Mahajan, S.K. Guha and M.M. Misro, ` Biogalyanic cell for male Contraception', Medical Research Engg. 7, 11-15 (1981).

  11. K. Verma, M.M. Misro, Harpal Singh, Sudha Mahajan, A.R. Ray and S.K.Guha, ‘Histology of the Rat Vas Deferens after Injection of the Noncclusive Chemical Contraceptive'.  J. Reprod. Fertility, 63, 539-542 (1981).

  12. M.M. MIsro, Harpreet Kaur, Sudha Mahajan and S.K. Guha,`An Intravasal Nonocclusive Reversible Contraceptive Device  in Male',  J. Reprod. Fert., 65, 9-13 (1982).

  13. Sudha Mahajan, S.K. Guha and M.M. Misro,  `A Theoretical and SEM Study of current Mediated Mortality of Spermatozoa', J. Biol. Physics, 10, 113-118 (1982).

  14. S.K.Guha  and Sudha Mahajan, `Infrared  Relectance  from whole  Blood  Soaked  Filter  paper  and  Implications in Haemglobimetry',  Med. Biol. Engg.,   21, 97-100 (1983).

  15. Gita Subba Rao, Sudha Mahajan and R.K. Mishra,`Calculation of Minimum Energy  Conformation of  Biomolecules  using  a Global  optimization Technique. IV preferred conformation and Receptor Maps of Histamine’ Int. J. Quantum Chem.  10, 5-9 (1983).

  16. Gene, A.Morril, Adele B. Kostellow, Sudha Mahajan and  Raj K. Gupta,  Role of Calcium in regulating  intracellular  pH following  the stepwise release of the metabolic  blocks  at first  meiotic  prophase  and second  meiotic  metaphase  in amphibian  oocytes. Biochimica et. Biophysica Acta, 804, 104-117 (1984).

  17. R.Tabeta, Sudha Mahajan, M.Maeda and H. Saito, `Interaction of      Antidepressant  Drugs  with Lipid Bilayers studied  by  High Resolution  13C and High Power 1H NMR Spectroscopy: the manner of binding as viewed from the differential line broadening of 13C NMR Signals'. Chem. Pharm. Bull., 33, 5, 1793-1807 (1985).

  18. Sudha Mahajan, P.S.Maruthi Sai and A. Kumar. A study of Photogluminescence of light harvesting    complexes   in Cynobcterium. J. Luminescence, 40 & 41, 231-232, 1988.

  19. P.S. Maruthi Sai and Sudha Mahajan.  Excitation energy transfer among phycobilisomes from phycoerythrin containing strain Anabaena variabilis ARM 310 In Current Research  in Photosynthesis.Vol.II  (Ed, Baltscheffski, M) (1990)  Kluwer Academic Publisher, Netherland.

  20. D.R. Shukla and Sudha Mahajan. Conformational behaviour of Tachykinins.In Expanding Frontiers in Polypeptide and Protein Research, Escom, Netherlands, 1990. pp.85-91.

  21. P.S.  Maruthi  Sai, S. Siebzenruebl, Sudha  Mahajan  and  H. Scheer,   Phycoerythrocyanins from Westiellopsis Prolifica and Nostoc virulare: Characterization of the Phycoviolobilin chromophore in both states. Photochem.Photobiol. 55, 1, 119-124 (1992).

  22. Xia Andong, Zhang Xinyi, M. Sudha, P.S. Maruthi Sai and I.B. Jha,    Resonance   Raman  scattering   of   phycobilisomes, phycobiliproteins  from    Cyanobacterium  Westiellopsis prolifica, Science in China, 37, 2, 550-553 (1992).

  23. Xia Andong,  Zhang  Xinyi,  Hong  Qiang,  Menj  Jiwu,   Hou Shangong,   M.   Sudha,   P.S.  Maruthi   Sai,   I.B.   Jha,  Spectroscopic  characterisation  and energy  tansfer  in  C-phycocyanin  from  cyanobacterium  Westiellopsis  prolifica, Science in China (Series B), 35, 2, 156-164 (1992).

  24. P.S. Maruthi Sai, S. Siebzehnrubl, Sudha Mahajan and H. Scheer: Fluorescence and circular dichroism studies from the cyanobacterium Westiellopsis prolifica.  Photochemistry and Photobiology, 57, 71-75 (1993).

  25. Maria L. Ghirardi, Sudha Mahajan, Sudhir K. Sopory,  Marvin Edelman and Antar K. Mattoo, Photosystem II reaction  center particle  from  Spirodela  stroma  lamellae.Journal  of  Biological Chemistry, 268, 5357-5360 (1993).

  26. Xia  Andong,  J.  Zhu, H. Wu, L.  Jiang, ZhangXinyi,  Sudha Mahajan,P.S. Maruthi Sai.   Time-resolvespolarizedabsorption of  C-phycocyanin  from  the  cyanobacterium   Westiellopsis prolifica   phycobiliproteins   and   phycobilisomes  from cyanobacteria   Westiellopsis   Prolifica,  J. Photochem. Photobiol, 19 , 111-117 (1993).

  27. Sudha Mahajan, Chritian Lucke and H.Ruterjans, ‘Lipid induced conformation of physnalamin’, J. Biomolecular Str. and Stereodynamics, 113, (1993).

  28. Anil Saran , D.R.Shukla and SudhaM.Cowsik,Quantum mechanical studies on neuropeptides:Confornmationa of C-terminal tetra and pentapeptides of tachykinins, J.Mol.Structure (Theochem),  361, 243-248 (1996).

  29. D.R.Shukla and Sudha M.Cowsik ‘Conformational behavior of substance P determined by NMR spectroscopy and CD spectropolarimetry’, Proc. Nat.Acad.Sci. (India), 66, 217-235 (1996).

  30. Sudha M.Cowsik and S.Swaminathan, ‘A magnetic resonance study of solution conformation of antidepressant drugs of imipramine and anitryptyline: evidence for two receptor sites’, Proc. Nat. Acd. Sci. (India), 66, 46-61, (1996).

  31. Sudha M.Cowsik, Christian Lucke and H.Ruterjans, ‘Lipid induced conformation of substance P’, J.Biomolecular Str. and Stereodynamics,  15: 27-36, (1997).

  32. S.Mukhopadhyay, Sudha M.Cowsik, Andrew M.Lynn, W.W.Welsh and Allyn Howlett, ‘Regulation of G by CR1 Cennabinoid  Recepta C-Terminal justamembrance region: Structural requirements determined by Peptide Analysis’, Biochemistry,  38: 3447-3455 (1999).

  33. A. Thakur, H.D. Kumar, Sudha M. Cowsik, ‘Effect of pH and inorganic carbon concentration on growth, glycerol production photosynthesis and dark respiration of Dunaliella salina.’Cytobios, 102(400): 69-74 (2000).

  34. C.R. Grace, Andrew M. Lynn and Sudha M. Cowsik  'Lipid induced conformation of tachykinin peptide kassinin', J. Biomolecular Str. And Stereodynamics,18(4):611-625(2001).

  35. Indu R. Chandrashekar, Sara R. Davey, R. Benigni,  P.K. Yadava and Sudha M. Cowsik,  ‘A case study of thermostability in phycobiliproteins using algorithm recurrence quantification analysis’ Australian J. Plant Physiology,  ( 2001).

  36. C.R.Grace, Indu Chandrasheker and Sudha M. Cowsik, ‘Solution conformation of the tachykinin peptide Eledoisin.’  Biophysical J.  84 (1): 655-664(2002).

  37. Alessandro Giuliani, Romualdo Benigni, Mauro Colafranceschi,  Indu Chandrashekar and    Sudha M. Cowsik. ‘Large contact surface interactions between proteins detected by time series analysis methods: Case study on C-phycocyanins.’ Proteins: structure, function and genetics.  51(2): 299-310 (2003).

  38. Indu Chandrashekr and Sudha M. Cowsik, ‘Three Dimensional Structure of the mammalian Tachykinin peptide Neurokinin A bound to lipid micelles.’ Biophysical J.  85(6): 4002-4011 (2003).

  39. Indu R. Chandrashekar, M. Anil Kumar, Anjali  Dike and Sudha M. Cowsik ‘Solution Structure of NK2 Agonists’ J.Biomol. Struct. Dynamics, 20 (6): 945, (2003).

  40. Anil K. Mantha, Indu R. Chandrashekar, Najma Z. Baquer and Sudha M. Cowsik ‘Three Dimensional Structure of the mammalian Tachykinin peptide Neurokinin B bound to lipid micelles.’ Journal of biomolecular structure and dynamics. 22 (2): 137-147(2004).

  41. Indu R Chandrashekar, Anjali Dike and Sudha M Cowsik., ‘Membrane induced structure of the mammalian tachykinin Neuropeptide gamma’. Journal of Structural biology. 148: 315-325 (2004).

  42. K Moorthy , UC Yadav, Anil K Mantha, Sudha M Cowsik,  D Sharma,  SF Basir, NZ Baquer; Estradiol and progesterone treatments change the lipid profile in naturally menopausal rats from different age groups.’ Biogerontology. 5(6): 411-419(2004).

  43. Anjali Dike and Sudha M Cowsik., ‘Membrane induced structure of Scyliorhinin I: A dual NK1/NK2 agonist’. Biophysical Journal. 88:3592-3600. 2005.

  44. C.R.Grace,  Sudha M. Cowsik, Allyn C. Howlett and W.J.Welsh .’ Conformational Characterization of a peptide mimetic of the fourth cytoplasmic loop of the G-protein coupled cannabinoid receptor.’  (comm.).

IV.  Publications  in International Proceedings

  1. K. Sundaram and Sudha Mahajan,   ‘Drug Design Through  Receptor    Maps'   Proc. Int. Symp.Drug Design , CDRI., Lucknow 1976.

  2. Sudha Mahajan and S.K. Guha, `A New Approach to whole Blood Haemoglobinometry', 3rd National Conference (with  International  Participation) of Society of Biomedical Physics  and Enginnering,  Sofia, October 1980. 

  3. Sudha  Mahajan and  K.Sundaram,  `Receptor site  mapping  of tricyclic  antidepressants'.  Annual  Meeting  of   Western Japanese Society of  Neurology  and  Psychiatry.  Kyoto, October, 1981.

  4. Sudha  Mahajan and K. Sundaram,  `Receptor site  mapping  of tricyclic  antidepressants'.  Annual  Meeting  of  Western Japanese  Society of Neurology and  Psychiatry.    Hiroshima, 1981.

  5. Sudha  Mahajan,   `Computer Simulation  of  Molecular  Frame Works',   Symposium  on Medical  Informatics,   Delhi,  India, April 1982.

  6. Sudha  Mahajan, S.Srivastava and G.Govil, ‘Interaction of Antidepressant  Drugs  with  Membranes'   presented  at  the Sanibel  International  Symposium  in  Quantum  Biology  and Quantum Pharmacology , Florida, U.S.A (1983).

  7. Sudha Mahajan, R. Tabeta and H.  Saito, Drug Membrane Interactions   using NMR techniques. Presented at the Sanibel   International Symposium in QuantumBiology and Quantum Pharmacology, Florida, USA, 1985.

  8. P.S. Maruthi Sai, Sudha Mahajan and H.N. Singh, Picosecond fluorescence kinetics  of  energy transfer  across  intact phycobilisomes isolated from various cyanobacterial species.  Proc.  International  Phycotalk  Symposium,  Varanasi,India. December  1987.

  9. Sudha  Mahajan and S. Swaminathan,  `A  magnetic  resonances study  of solution conformation of anti depressant drugs  of imipramine  and  amitriptyline:  Evidence for  two  receptor sites’, Presented  at  XIII  International  Conference   of Magnetic Resonance in Biological Systems, Madison Wisconsin, USA August 1988.

  10. P.S. Maruthi Sai and Sudha Mahajan,  `A study of the  energy transfer   among  the  light  harvesting complexes from different  species of cyanobacteria with particulr emphasis on fluorescence life times', Presented at New Techniques and Developments  in Photosynthesis NATO/FEBS School,  Spetsei, Greece, August 1988.

  11. D.R.  Shukla and Sudha Mahajan, High resolution Proton NMR study of the conformation of substance P and its N-terminal Fragment, presented at 10th   International   Biophysics Congress, Vancouver, Canada, August 1990.

  12. D.R. Shukla and Sudha Mahajan, High resolution NMR study of temperature induced changes in conformation of substance P and its analogues, XIV International Conference on Magnetic resonance in Biological Systems, Warwick, England, September 1990.

  13. M.L.Ghirardi, S.Mahajan, S.K.Sopory, M.Edelman and A.K. Mattoo, Isolation and characterization of photosystem II reaction center from stroma lamellae, Presented at  Eastern Regional Photosynthesis Conference, Boston, M.A., 1990.

  14. M.L.Ghirardi, S. Mahajan, S.K. Sopory, M. Edelman and  A.K. Mattoo,  Photosystem  II  reaction centers  from  grana  and stroma  lamellae: isolation and  spectroscopic  comparisons, Presented at Gordon Conference, New Hampshire, M.A., 1990.

  15. Sudha Mahajan, D.R. Shukla and H. Ruterjans, Lipid induced     conformation of tachykinins. In proceedings XV International Conference of Magnetic Resonance in Biological Systems, Jerusalum, Israel, September 1992.

  16. D.R. Shukla, Sudha Mahajan and H.  Ruterjans, Solution conformation of   delta sleep inducing peptide. In proceedings XV International Conference of   Magnetic Resonance in Biological Systems, Jerusalum, Israel, September 1992.

  17. Z.A. rafi, Andrew Lynn, Sonia advni and Sudha M. Cowsik, “Molecular dynamics and its application to Biology’, Indo-US workshop on Chemical and Radiological Physics, New Delhi , October, 1993.

  18. Sudha Mahajan, Christian Lucke and H.Ruterjans, Lipid induced conformation of physaelamin. Proc. Eighth Conversation in Stereodynamics, Albany, New York, U.S.A., 1994.

  19. Sudha Mahajan and Andrew Lynn, Solution conformation of a tachykinin peptide, Neurokinin A, determined by CD and high resolution NMR Spectroscopy, proceedings XV International Conference of   Magnetic Resonance in Biological Systems,Colorado, USA, August 1996.

  20. Sudha M.Cowsik, S.Mukhopadhyay, W.W.Welsh and Allyn Howlett, ‘Molecular modeling and molecular dynamics simulation of a fragment (C-Terminal justamembrance region) of Cennabinoid Receptor, American Chemical Society meeting, Las Vegas, USA, November, 1997.

  21. C.R. Grace, Andrew M. Lynn and Sudha M. Cowsik 'Lipid induced conformation of tachykinin peptide kassinin and eledoisin, Proc. International Biophysics Congress, Delhi, India, 1999.

  22. Sudha M. Cowsik, Christy R. Grace, Christian Luecke and Heinz Ruterjans “Solution Structure of the Tachykinin Peptide Physaelamin”, XX International Conference of   Magnetic Resonance in Biological Systems, Toronto, Canada, August 2002.

  23. Sudha M. Cowsik, Christy R. Grace, Indu   R. Chandrashekar,W.W.Welsh and Allyn Howlett “Structural Characterization of a peptide mimetic of the fourth cytoplasmic loop of the G-protein coupled  receptor” Proc.International Biophysics Congress, Buenos Aires,Argentina,2002.

  24. Indu R. Chandrashekar, Anil K. Mantha, Anjali Dike and Sudha M. Cowsik. Three dimensional structure of lipid induced NK-2 selective tachykinin agonists. 13th Conversation, at Albany, USA June 17 to 21, 2003.

  25. Indu R. Chandrashekar, Anil K. Mantha, Anjali Dike and Sudha M. Cowsik. Lipid induced structure of Neurokinin-2 selective agonists BaCaTeC Summer School on “NMR of Biomolecular complexes”, at Bayreuth, Germany October 3 to 8, 2004.

  26. Anil K. Mantha, Indu R. Chandrashekar, K. Moorthy, Najma Z. Baquer and Sudha M. Cowsik. Tachykinin NK-3 Receptor and its Agonist Neurokinin B (NKB) Interactions: Shedding Light on Aging Brain Functions. IBRO Advanced School on Neuroscience “Receptors, Channels, Messengers”, at Yalta, Ukraine September 16 to 28, 2004.

  27. Anil K.Mantha, Indu R. Chandrashekar, Anjali Dike, K. Moorthy, Najma Z. Baquer and Sudha M. Cowsik.Role of Neurokinin B and Ab-protein fragment 25-35 on aging rat brain synaptosomes. The XXIst International Conference on Magnetic Resonance in Biological Systemsat Hyderabad India. , January 16 to 21, 2005.

  28. Indu R. Chandrashekar, Anil K. Mantha, Anjali Dike and Sudha M. Cowsik Structural features of Neurokinin-2 receptor selective peptide agonists and their role in receptor selectivity. The XXIst International Conference on Magnetic Resonance in Biological Systems, at Hyderabad, India January 16 to 21, 2005.

  29. Anjali Dike, Indu R. Chandrashekar, Anil K. Mantha and Sudha M. Cowsik.Structural characterization of Scyliorhinin I: A dual NK1/NK2 receptor agonist. The XXIst International Conference on Magnetic Resonance in Biological Systems, at Hyderabad, India January 16 to 21, 2005.

Teaching Experience

  1. Structural Biology and Molecular Biophysics course for M.S Final year students 1979 - till date at Indian Institute of Technology, Delhi and Jawaharlal Nehru University, Delhi.

  2. Physics and Instrumentation in Anaesthesiolgy course for post graduates of anaesthesiology Department at All India Institute of Medical Sciences, Delhi, 1979 - 1985.

  3. Undergraduate physics at Indian Institute of Technology, Delhi 1979 - 1985.

  4. Physics Life Sciences, M.Sc.  Life Sciences students, 1985 till date at Jawaharlal Nehru University, Delhi.

Top