Faculty Profile

 

Name : Uttam K.  Pati
Designation : Professor
Centre/School/Special Centre : School of Biotechnology
Room No : 115
Off. Phone : 26704081
Residence :
Email : uttam@mail.jnu.ac.in   
Personal webpage : http://www.jnu.ac.in/Faculty/ukpati

Qualifications

Ph. D. (Drug Design & Synthesis) University of New Brunswick, Canada, 1981
D. Phil (Chemistry), Allahabad University, 1978 
                                    

Areas of Interest/Specialization

Molecular chaperones and gene regulation, Tumor suppressor proteins and their role in tumor regression, Molecular mechanism of Hypoxia and apoptosis , Biomarkers  
                                    

Experience

2006-2007 Dean, School of Biotechnology
2005- 2006 Chairman, Centre for Biotechnology
2002 Professor
1999 - 2001 Chairman
1998 Acting Director, , JNU, Genetic Engineering Unit
1994-2002 Associate Professor
1990-1994 Assistant Professor of Medicine & Molecular Biology, School of Medicine, Augusta, Georgia, USA
1986-1990 Associate Research Scientist, Yale University School of Medicine, CT, USA
1983-1985 Research Associate, Yale University, CT, USA
1982-1983 Research Associate, Massachusetts Inst. of Technology, Cambridge, USA
1981-1982 Post doctoral Research Fellow, Max-Planck Inst, Germany
1976-1978 Lecturer in Chemistry, Regional College of Education, Bhubaneswar 
                                    

Awards & Honours

American Cancer Society Award 1992-95
MCG (Georgia) Institutional Award 1991-92
Swebilus Cancer Research Award 1990
American Cancer Society Travel Award 1990
Yale Research Fellowship 1983-85
MIT Research Fellowship 1982-83
Max-Planck Fellowship 1981-82
Univ. of New Brunswick Teaching Assistantship 1978-81
CSIR Junior Fellowship 1975-78
 
                                    

International Collaboration/Consultancy

University Vienna, Austria
Ohio State University, USA
AIIMS, New Delhi 
                                    

Best Peer Reviewed Publications (upto 5)

1. Esha Madan, Rajan Gogna, Periannan Kuppusamy, Madan Bhatt, Abbas Ali Mahdi, Uttam Pati. SCO2 Induces p53-Mediated Apoptosis by Thr845 Phosphorylation of ASK-1 and Dissociation of ASK-1-TRX Complex. Mol. Cell. Biol. doi:10.1128/MCB.06798-11, 2013

2. R Gogna, E Madan, P Kuppusamy, U Pati. Re-oxygenation causes hypoxic tumor regression through restoration of p53 wild type conformation and post-translational modifications, Cell Death & Disease 3, e286; doi:10.1038/cddis.2012.15 & 2012 Macmillan Publishers Limited

3. R Gogna, E Madan, P Kuppusamy, U Pati. P53 core domain modifications determine apoptotic and necrotic death in cancer cells. Antioxidant & Redox Signaling, 16, 400-412, 2011. (2011 (doi: 10.1089/ars.2011.4103)

4. V tripathi, A Ali, R Bhat, U Pati. CHIP chaperones wild type p53 tumor suppressor protein. Jour Biol Chem, 282, 39, 2007, 28441-454

5. R Gogna, E Madan, P Kuppusamy, U Pati. Chaperoning of Mt p53 by Wt p53 causes hypoxic tumor regression. Jour Biol Chem, 287, No.4, 2907-2914, 2012 Published on December 6, 2011 as Manuscript M111.317354  
                                  

Recent Peer Reviewed Journals/Books (upto 3)

1. E Madan, R Gogna , P Kuppusamy , M Bhatt , U Pati *, A Ali Mahdi * TIGAR Induces p53-Mediated Cell-Cycle Arrest by Regulation of RB-E2F1 Complex. British Jour Cancer 2012

2. E Madan , R Gogna , U Pati. p53Ser15 Phosphorylation disrupts p53-RPA70 complex and induces RPA70- mediated DNA repair in hypoxia, Biochem Jour 443, 0000 2012(Printed in Great Britain) doi:10.1042/BJ20111627 2012

3. R Gogna, E Madan, B Keppler, U Pati. Gallium compound GaQ3-induced Ca2+ signaling triggers p53-dependent and independent apoptosis in cancer cells, British Jour Pharmacology,2011. doi: 10.1111/j.1476-5381.2011.01780  
                                    

Patents (if any)