Dr. Dipankar Ghosh received his Ph.D. from Jadavpur University, Calcutta. He carried on postdoctoral research in the Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Ohio, USA. Dr. Ghosh received the Merlin Bumpus Investigator Award, USA in 2001.

Research Interest

A myriad of innate immune determinants play critical role in mammalian host defense against infectious threat. These factors often precede the temporal profiles of adaptive immunity and therefore act as the ‘first line of defense’ against infection. Among the most significant of these innate immune determinants are cationic antimicrobial peptides (like lysozyme and defensins) – that confer broad spectrum innate immunity to the host. It is also understood that these peptides and related determinants play significant role in modulating microbial colonization and endogenous flora in the host. Dr. Ghosh is interested in exploring the relationships between such innate immune determinants and microbial biofilm formation in specific physiological niche.

Recent Publications:

1.       Ghosh D, Salzman NH, Huttner KM, Paterson Y, Bevins CL. Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin. Nature. 2003 422:522-6.

2.       Ghosh D, Porter E, Shen B, Lee SK, Wilk D, Drazba J, Yadav SP, Crabb JW, Ganz T, Bevins CL. Paneth cell trypsin is the processing enzyme for human defensin-5. Nat. Immunol. 2002 3:583-590.