Sudha Bhattacharya
Ph. D., F.A.Sc., F.N.A.Sc.
Professor and Dean, SES, JNU
School of Environmental Sciences
Jawaharlal Nehru University
New Delhi-110 067

Educational and Professional Record:

Institution
Degree/Post    
Year
Field of study/Research
University of Delhi,
Delhi 
B. Sc.(Hons.)
1971
Botany (main), Zoology, Chemistry  
Indian Agricultural Research Institute,
New Delhi 
M. Sc.
1973
Biochemistry (main), Genetics, Microbiology
Indian Agricultural Research Institute,
New Delhi 
Ph. D.
1977
Biochemistry
Stanford University,
USA
Post-doctoral
1977-1979
Bacteriophage genetics
Boston Biomedical Research Institute,
USA     
Staff-fellow
1979-1981
Bacterial DNA Replication
All India Institute ofMedical Sciences, 
New Delhi            
Research Officer  
1981 -1982 
Genetic engineering in Mycobacteria
Tata  Research  Development & Design Centre,
Pune
Scientist
1982-1985
Development of  DNA probes for tuberculosis and other diseases
National Institutes of Health,
U.S.A.
World Bank Fellow
1985-1986
Repetitive DNA in Entamoeba histolytica
Jawaharlal Nehru University,
New Delhi
Assistant Professor
1986-1995
Molecular biology of amoebiasis
Jawaharlal Nehru University,
New Delhi
Associate Professor
1995-2003
Molecular biology of amoebiasis
Jawaharlal Nehru University,
New Delhi
Professor
2003-present
Molecular biology of amoebiasis

Awards:

National Science Talent Search Scholarship (1968)       
Merit  position  in  Central  Board  of  Secondary  Education (1968)       
Robert Mc Namara Fellow of World Bank (1985)
Rockefeller Biotechnology Career Development Award (1987)
Fogarty International Research Collaboration Award (1996)
Fogarty International Research Collaboration Award (2001)

Honours:

Member of Guha Research Conference (1993)
Fellow of the Indian Academy of Sciences, Bangalore (2001)
Fellow of the National Academy of Sciences, Allahabad (2008)

List of Publications:

  1. S. Sehgal and H.K. Das (1980) Mis-transcription  during  uridine  starvation  in  Escherichia  coli  K12. J. Gen. Microbiol. 116: 243-247.
  2. S. Bhattacharya and H.K. Das (1980) Noncoordinate control of the synthesis of different species of RNA in E. coli  K12 during uridine starvation.  Mol. Biol. Reports  6: 73-77. 
  3. S. Bhattacharya  and  N.  Sarkar  (1981)  Study of  DNA  replication  in permeable cells of Bacillus subtilis using mercurated  nucleotide substrates.  Biochemistry  20: 3029-3034.                
  4. S. Bhattacharya and N. Sarkar (1981) Inhibition of DNA replication in Bacillus brevis by RNA Polymerase inhibitors. J. Bacteriol. 145: 1142-1144.
  5. S. Bhattacharya and N. Sarkar (1981)  ATP requirement for  in  vitro  DNA synthesis in permeable cells of Bacillus  brevis. Biochem. Biophys. Acta  653: 289-293.          
  6. S. Bhattacharya  and N. Sarkar (1982) Transforming activity of mercury-substituted DNA synthesized in vitro by permeable cells of Bacillus subtilis. J. Biol. Chem.  257: 1610-1612.
  7. S.  Bhattacharya, A. Bhattacharya, S. Trehan and G.P.  Talwar (1984)  Molecular  cloning  of  Mycobacterium  tuberculosis H37Ra DNA in E. coli. Ind. J. Biochem. Biophys. 21: 201-202.
  8. G. Banfalvi,  S. Bhattacharya and N. Sarkar (1985)  Selective isolation of mercurated DNA by affinity  chromatography  on  thiol matrices. Anal. Biochem. 146: 64-70.
  9. S.N. Ranadive, S. Bhattacharya,  M.K.  Kale and  A. Bhattacharya (1986) Humoral immune    response  in  tuberculosis: initial  characterization  by  immuno-precipitation of 125-Iodine labelled antigens  and  sodium dodecyl  sulfate polyacrylamide gel  electrophoresis.  Clin. Exp. Immunol. 64: 277-284.       
  10. S. Bhattacharya, S.N. Ranadive and A. Bhattacharya  (1986). Expression of Mycobacterium tuberculosis genes in E. coli. J. Biosci. 10: 277-281.      
  11. A. Bhattacharya,  S.N. Ranadive,  M.K. Kale  and   S. Bhattacharya  (1986)  Antibody based   enzyme linked immunosorbent assay for determination of immune-complexes in clinical tuberculosis. Am. Rev. Resp. Dis. 134: 205-209.        
  12. S. Bhattacharya, S.N. Ranadive and A. Bhattacharya  (1988)  Distinction of  Mycobacterium  tuberculosis from other mycobacteria through DNA hybridization. Ind. J. Med. Res. 87: 144-150.       
  13. S. Bhattacharya,  A. Bhattacharya and L.S.  Diamond  (1988)  Comparison of  repeated DNA  from strains of  Entamoeba histolytica  and other Entamoeba. Mol. Biochem. Parasitol. 27: 257-262.       
  14. S. Bhattacharya, A. Bhattacharya, L.S. Diamond and A.T. Soldo (1989)  Circular  DNA  of  Entamoeba histolytica encodes ribosomal RNA. J. Protozool. 36: 455-458.       
  15. S. Bhattacharya,  A. Bhattacharya and L.S. Diamond (1989)  Molecular comparisons among E. histolytica strains using DNA and  protein  profiles. In "Progress in vaccinology"  Vol. 2,  pp. 253-258 (G.P. Talwar, ed.) Springer-Verlag.       
  16. A. Bhattacharya,  S. Bhattacharya, M.P. Sharma  and  L.S. Diamond (1990)  Metabolic labelling of Entamoeba histolytica antigens:  Characterization of a 28 kD  major  intracellular antigen. Exp. Parasitol. 70: 255-263.      
  17. A. Bhattacharya,  R. Ghildyal,  S. Bhattacharya  and  L.S. Diamond (1990)  Characterization of a monoclonal antibody that selectively recognizes a subset of Entamoeba histolytica isolates. Infect. Immun. 58: 3458-3461.       
  18. S. Babu, N.K. Jain, G. Prasad, S. Bhattacharya and A. Bhattacharya (1990) Characterization of cell-wall  derived polypeptide antigens from different species of mycobacteria. J. Med. Microbiol. 32: 263-269.       
  19. V. Mittal, S. Ramachandran, D. Sehgal,  A. Bhattacharya and S. Bhattacharya (1991) Sequence analysis of a DNA  fragment with  yeast autonomously replicating sequence activity  from the  extrachromosomal  ribosomal  DNA circle of  Entamoeba histolytica. Nucl. Acids Res.  19: 2777.
  20. A. Bhattacharya, S. Bhattacharya and D. Sehgal (1991). Molecular basis of immune response against parasites. Curr. Sci.  60: 569-580.
  21. S. Bhattacharya, A. Bhattacharya and L.S. Diamond (1992)  E. histolytica  extrachromosomal circular DNA:  Analysis of clonal variation in a hypervariable region.  Exp. Parasitol. 74: 200-204.   
  22. A. Bhattacharya, R. Ghildyal, J. Prasad, S. Bhattacharya  and L.S.  Diamond (1992)  Modulation of a surface antigen of Entamoeba histolytica in response to bacteria. Infect. Immun.  60: 1711-1713.
  23. V.Mittal,  D. Sehgal, A. Bhattacharya and S. Bhattacharya (1992).  A second short repeat sequence detected  downstream of  rRNA  genes in the Entamoeba histolytica rRNA episome.  Mol. Biochem. Parasitol. 54: 97-100.
  24. J. Prasad, S. Bhattacharya and A. Bhattacharya (1992)  Cloning and sequence analysis of a calcium binding protein gene from a pathogenic strain of Entamoeba histolytica. Mol.  Biochem Parasitol. 52, 137-140.
  25. R.  Prasad,  M. Tola,  S. Bhattacharya,  M.P. Sharma and  A. Bhattacharya (1992)  Recognition of  Entamoeba histolytica Lipophosphoglycan by a strain-specific monoclonal    antibody and human immune sera. Mol. Biochem. Parasitol. 56,  279-288.  
  26. S. Ramachandran, A. Bhattacharya and S. Bhattacharya (1993) Nucleotide sequence analysis of the rRNA transcription unit of  a  pathogenic Entamoeba histolytica strain  HM-1:  IMSS. Nucl. Acids Res. 21,  2011.
  27. D. Sehgal,  A. Bhattacharya  and  S. Bhattacharya  (1993)  Analysis of a polymorphic locus present upstream of  rDNA  transcription units in the extrachromosomal circle of  Entamoeba histolytica. Mol. Biochem Parasitol. 62, 129-130.
  28. J. Prasad, S. Bhattacharya and A. Bhattacharya  (1993) The  Calcium  binding  protein  of  Entamoeba  histolytica:  Expression   in   Escherichia coli  and    immunochemical   characterisation. Cell. Mol. Biol. Res. 39, 167-175.
  29. V. Mittal, A. Bhattacharya and S. Bhattacharya  (1994)  Isolation and characterization of a species-specific multicopy DNA sequence from Entamoeba histolytica. Parasitology, 108, 237-244.
  30. D.  Sehgal,  V.  Mittal,  S.  Ramachandran,  S.K.Dhar,   A. Bhattacharya and S. Bhattacharya (1994) Nucleotide  sequence organisation  and analysis of the  nuclear  ribosomal  DNA  circle of the protozoan parasite Entamoeba histolytica. Mol. Biochem. Parasitol. 67, 205-214.
  31. S. K. Dhar, N. Roy Choudhary, A. Bhattacharya and S. Bhattacharya (1995) A multitude of circular DNAs exist in the nucleus of Entamoeba histolytica. Mol. Biochem. Parasitol. 70, 203-206.
  32. G. Srivastava, M. Tola Anand, S. Bhattacharya and A. Bhattacharya (1995) Lipophosphoglycan is present in distinctly different form in different Entamoeba histolytica strains and absent in Entamoeba moshkovskii and Entamoeba invadens. J. Euk. Microbiol. 42, 617-622.
  33. S. K. Dhar, N. Roy Choudhary, V. Mittal, A. Bhattacharya and S. Bhattacharya (1996) Replication initiates at multiple random sites in the ribosomal DNA plasmid of the protozoan parasite Entamoeba histolytica. Mol. Cell Biol. 16, 2314-2324.
  34. A. Azam, J. Paul, D. Sehgal, J. Prasad, S. Bhattacharya and A.Bhattacharya
    (1996) Identification of novel genes from Entamoeba histolytica by expressed sequence tag analysis. Gene 181, 113-116.
  35. S.Tiwari, A.Bhattacharya, S.Bhattacharya and R.Ramaswamy1996)
    Gene identification in silico. Current Science 71, 12-24.
  36. D. Sehgal, A. Bhattacharya and S. Bhattacharya (1996) Pathogenesis of infection by Entamoeba histolytica. J. Biosc. 21, 423-432.
  37. S. Tiwari, S. Ramachandran, A. Bhattacharya, S. Bhattacharya and R. Ramaswamy (1997) Prediction of probable genes by fourier analysis of genomic sequences. CABIOS 13, 263-270.
  38. B. Gopal, C.P.Swaminathan, S. Bhattacharya, A. Bhattacharya, M.R.Murthy and A. Surolia (1997) Thermodynamics of metal ion binding and denaturation of a calcium binding protein from Entamoeba histolyticaBiochemistry 36, 10910-10916.
  39. N. Yadava, M.R. Chandok, J. Prasad, S. Bhattacharya, S.K. Sopory and A. Bhattacharya (1997) Characterization of EhCaBP, a calcium binding protein of E. histolytica, and its binding proteins. Mol. Biochem. Parasitol. 84, 69-82.
  40. A. Olvera, F. Olvera, R.R. Vines, F. Recillas-Targa, P.M.Lizardi, S. Dhar, S. Bhattacharya, W.Petri and A. Alagon (1997)  Stable transfection of E. histolytica trophozoites by lipofection. Arch. Med. Res. 28, 49-51.
  41. S. Bhattacharya, I. Som and A. Bhattacharya (1998) The Ribosomal DNA Plasmids of Entamoeba. Parasitology Today 14, 181-185.
  42. S. K. Dhar, R. R. Vines. S. Bhattacharya and W. A. Petri (1998) Ribosomal
    DNA fragments enhance the stability of transfected DNA in Entamoeba histolytica. J. Euk. Microbiol. 45, 656-660.
  43. A. Bhattacharya, M.T.Anand, J.Paul, N, Yadava and S. Bhattacharya
    (1998) Molecular changes in Entamoeba histolytica in response to bacteria. J. Euk. Microbiol. 45, 28S-33S.
  44. A. Bhattacharya. S. Bhattacharya and J. P. Ackers (1999) Nontranslated polyadenylated ribonucleic acids from the protozoan parasite Entamoeba histolytica. Curr. Science  77, 564-567.
  45. A. Bagchi, A. Bhattacharya and S. Bhattacharya  (1999)  Lack of a chromosomal copy of the circular rDNA plasmid of Entamoeba histolyticaIntl. J. Parasitol.  29,  1775-1783.
  46. R. Sharma, A. Azam, S. Bhattacharya and A. Bhattacharya (1999) Identification
    of novel genes of nonpathogenic Entamoeba dispar by expressed sequence tag
    analysis. Mol Biochem. Parasitol. 99, 279-285.
  47. A. Bhattacharya, S. Bhattacharya, A. Joshi, S. Ramachandran and R. Ramaswamy
    (2000) Identification of parasitic genes by computational methods. Parasitol. Today 16, 127-131.
  48. A. Bhattacharya, S. Satish, A. Bagchi and S. Bhattacharya (2000) The genome
    of Entamoeba histolytica. Int. J. Parasitol. 30, 401-410.
  49. I. Som, A. Azam, A. Bhattacharya and S. Bhattacharya (2000) Inter- and
    intra-strain variation in the 5.8S ribosomal RNA and internal transcribed spacer
    sequences of Entamoeba histolytica and comparison with Entamoeba dispar,
    Entamoeba moshkovskii and Entamoeba invadens. Int. J. Parasitol. 30, 723-728.
  50. R. Sharma, A. Bagchi, A. Bhattacharya and S. Bhattacharya  (2001)  Characterization of a
    retrotransposon-like element in Entamoeba histolytica. Mol. Biochem. Parasitol. 116, 45-53.
  51. S. Ghosh, M. Zaki, C.G.Clark and S. Bhattacharya  (2001)  Recombinational loss of a ribosomal DNA unit from the circular episome of Entamoeba histolytica HM-1:IMSS.  Mol. Biochem. Parasitol. 116, 105-108.
  52. S. Bhattacharya, A. Bakre and A. Bhattacharya (2002) Mobile genetic elements in
    protozoan parasites. J. Genet. 81, 73-86.
  53. J. Paul, A. Bhattacharya and S. Bhattacharya (2002) Close sequence identity between ribosomal DNA episomes of the nonpathogenic Entamoeba dispar and pathogenic Entamoeba histolytica. J. Biosci. 27, 619-627.
  54. R. Arya, A. Mehra, R. Viswakarma, S. Bhattacharya and A. Bhattacharya (2003)
    Biosynthesis of Entamoeba histolytica proteoglycan in vitro. Mol. Biochem. Parasitol. 126, 1-8.
  55. N. Sahoo, S. Bhattacharya and A. Bhattacharya (2003) Blocking the expression of a
    calcium binding protein of the protozoan parasite Entamoeba histolytica by tetracycline regulatable antisense RNA. Mol. Biochem. Parasitol. 126, 281-284.
  56. S. Ghosh, S. Satish, S. Tyagi, A. Bhattacharya and S. Bhattacharya (2003) Differential use of multiple replication origins in the ribosomal DNA episome of the protozoan parasite Entamoebahistolytica. Nucleic Acids Res. 31, 2035-2044.
  57. A. Bhattacharya, S. Bhattacharya and J. P. Ackers (2003) Nontranslated polyadenylated
    RNAs from Entamoeba histolytica. Trends Parasitol. 19, 286-289.
  58. S. Satish, Abhijeet A. Bakre, S. Bhattacharya and A. Bhattacharya (2003) Stress-dependent
    expression of a polymorphic, charged antigen in the protozoan parasite Entamoeba
    histolytica. Infect. Immun. 71, 4472-4486.
  59. P. K. Mandal, A. Bagchi, A. Bhattacharya and S. Bhattacharya (2004) An Entamoeba
    histolytica LINE/SINE pair inserts at common target sites cleaved by the restriction enzyme-like LINE-encoded endonuclease. Eukaryotic Cell, 3, 170-179.
  60. P. Chakrabarty, D. K. Sethi, N. Padhan, K. J. Kaur, D. M. Salunke, S. Bhattacharya and A. Bhattacharya (2004) Identification and characterization of EhCaBP2: A second member of the calcium-binding protein family of the protozoan parasite Entamoeba histolytica. J. Biol. Chem. 279, 12898-12908.
  61. N. Sahoo, E. Labruyere, S. Bhattacharya, P. Sen, N. Guillen and A. Bhattacharya (2004) Calcium binding protein 1 of the protozoan parasite Entamoeba histolytica interacts with actin and is involved in cytoskeleton dynamics. J. Cell Sci. 117, 3625-3634.
  62. Loftus B, Anderson I, Davies R, Alsmark UC, Samuelson J, Amedeo P, Roncaglia P, Berriman M, Hirt RP, Mann BJ, Nozaki T, Suh B, Pop M, Duchene M, Ackers J, Tannich E, Leippe M, Hofer M, Bruchhaus I, Willhoeft U, Bhattacharya A, Chillingworth T, Churcher C, Hance Z, Harris B, Harris D, Jagels K, Moule S, Mungall K, Ormond D, Squares R, Whitehead S, Quail MA, Rabbinowitsch E, Norbertczak H, Price C, Wang Z, Guillen N, Gilchrist C, Stroup SE, Bhattacharya S, Lohia A, Foster PG, Sicheritz-Ponten T, Weber C, Singh U, Mukherjee C,             El-Sayed NM, Petri WA Jr, Clark CG, Embley TM, Barrell B, Fraser CM, Hall N. (2005) The genome of the protist parasite Entamoeba histolytica. Nature. 433 (7028), 865-8.
  63. A. A. Bakre, K. Rawal, R. Ramaswamy, A. Bhattacharya and S. Bhattacharya (2005) The LINEs and SINEs of Entamoeba histolytica: Comparative analysis and genomic distribution. Exp. Parasitol. 110, 207-213.
  64. S. Srivastava, S. Bhattacharya and J. Paul (2005) Species- and strain-specific probes derived from repetitive DNA for distinguishing Entamoeba histolytica and Entamoeba dispar. Exp. Parasitol. 110, 303-308.
  65. D. Vats, R. A. Vishwakarma, S. Bhattacharya, and A. Bhattacharya (2005)Reduction of Cell Surface Glycosylphosphatidylinositol Conjugates in Entamoeba histolytica by Antisense Blocking of E. histolytica GlcNAc-Phosphatidylinositol Deacetylase Expression: Effect on Cell Proliferation, Endocytosis, and Adhesion to Target Cells. Infect. Immun. 73, 8381-8392.
  66. P. K. Mandal, K. Rawal, R. Ramaswamy, A. Bhattacharya, and S. Bhattacharya (2006) Identification of insertion hot spots for non-LTR retrotransposons: computational and biochemical application to Entamoeba histolytica. Nucl. Acids Res. 34, 5752-5763.
  67. R. Rani, R. S. Murthy, S. Bhattacharya, V. Ahuja, M. A. Rizvi and J. Paul (2006) Changes in bacterial profile during amebiasis: demonstration of anaerobic bacteria in ALA pus samples. Am. J. Trop. Med. Hyg. 75, 880-885.
  68. J. Paul, S. Srivastava and S. Bhattacharya (2007) Molecular methods for diagnosis of Entamoeba histolytica in a clinical setting: An overview. Exp. Parasitol. 116, 35-43. 
  69. C.G. Clark, U.C.M. Alsmark, M. Tazreiter, Y. Saito‐Nakano, V. Ali, S. Marion, C. Weber, C. Mukherjee, I. Bruchhaus, E. Tannich, M. Leippe, T. Sicheritz‐Ponten, P.G. Foster, J. Samuelson, C.J. Noël, R.P. Hirt, T.M. Embley, C.A. Gilchrist, B.J. Mann, U. Singh, J.P. Ackers, S. Bhattacharya, A. Bhattacharya, A. Lohia, N. Guillén, M. Duchêne, T. Nozaki and N. Hall (2007)
    Structure and Content of the Entamoeba histolytica Genome. Advances in Parasitology
    Volume 65, 51-190   Edited by R. Muller, D. Rollinson and S.I. Hay, (358 pp.)
  70. A. Jhingran, P. K. Padmanabhan, S. Singh, K. Anamika, A. A. Bakre, S. Bhattacharya, A. Bhattacharya, N. Srinivasan and R. Madhubala (2008) Characterization of the Entamoeba histolytica Ornithine Decarboxylase-Like Enzyme. PLoS Negl Trop Dis. 2, e115.
  71. R. Jain, J. Santi-Rocca, N. Padhan, S. Bhattacharya, N. Guillen and A. Bhattacharya (2008) Calcium binding protein 1 of Entamoeba histolytica transiently associates with phagocytic cups in a calcium-independent manner. Cell. Microbiol. 10, 1373-1389.
  72. S. K. Panigrahi, G. D. Jhingan, I. Som, A. Bhattacharya, W. A.. Petri Jr. and S. Bhattacharya (2009) Promoter analysis of palindromic transcription units in the ribosomal DNA circle of Entamoeba histolytica. Euk. Cell. 8, 69-76.
  73. G. D. Jhingan, S. K. Panigrahi, A. Bhattacharya and S. Bhattacharya (2009) The nucleolus in Entamoeba histolytica and Entamoeba invadens is located at the nuclear periphery. Mol. Biochem. Parasitol. 167, 72-80.
  74. R. Jain, S. Kumar, S. Gourinath, S. Bhattacharya and A. Bhattacharya (2009) N- and C-terminal domains of the calcium binding protein EhCaBP1 of the parasite Entamoeba histolytica display distinct functions. PLoS ONE. 4(4):e5269. Epub 2009 Apr 22.
  75. P. Singh, P. Bandyopadhyay, S. Bhattacharya, A. Krishnamachari, and S. Sengupta (2009) Riboswitch Detection Using Profile Hidden Markov Models. BMC Bioinformatics, 10, 325-337.
  76. Jain R, Shrimal S, Bhattacharya S, Bhattacharya A (2010) Identification and partial characterization of a dynamin-like protein, EhDLP1, from the protist parasite Entamoeba histolytica. Eukaryot Cell. 2010 Jan;9(1):215-23. Epub 2009 Nov 13.
  77. Clark CG, Gillin FD, Bhattacharya A, Bhattacharya S, Mirelman D (2010)
    In memoriam: Louis S. "Buddy" Diamond (1920-2009).J Eukaryot Microbiol. Sep-Oct;57(5):449-51. Epub 2010 Jul 15
  78. Shiteshu Shrimal, Sudha Bhattacharya, and Alok Bhattacharya (2010) Serum-Dependent Selective Expression of EhTMKB1-95, a Member of Entamoeba histolytica B1 Family of Transmembrane Kinases. PLoS Pathogens, Jun 3;6(6):e1000929.
  79. Singh N, Bhattacharya S, Paul J (2011) Entamoeba invadens: dynamics of DNA synthesis during differentiation from trophozoite to cyst.
    Exp Parasitol. 2011 Feb;127(2):329-33. Epub 2010 Aug 19.
  80. Somlata, Bhattacharya, S., & Bhattacharya, A (2011) A C2 domain protein kinase initiates phagocytosis in the protozoan parasite Entamoeba histolytica. Nature Commun. In press.

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