Prof. Uttam K Pati
 

Dr. Uttam K Pati
Professor
Ph: +91 11 26704081
Email: uttam@mail.jnu.ac.in ; uttamkpati@yahoo.co.in

Education

Ph. D. , University of New Brunswick, Canada
D. Phil, Allahabad University, Allahabad

Career:

2002-
Professor, School of Biotechnology, JNU, New Delhi.
1998
Acting Director, Genetic Engineering Unit, JNU, New Delhi
1994-2002
Associate Professor, Special Centre for Biotechnology, JNU, New Delhi.
1990-1994
Assistant Professor of Medicine & Molecular Biology, Medical College of Georgia, Augusta, USA
1984-1989
Research Scientist, Yale University School of Medicine, USA
1983
Post Doctoral Research Fellow, Massachusetts Institute of Technology, USA
1982
Post Doctoral Research Fellow, Max-Planck Institute, Germany

Area of Interest:

Molecular chaperones & gene regulation, Molecular mechanism of hypoxia, cancer biology, Tumor suppressor protein p53, Biomarkers.

Honors/Awards:

  • Medical College of Georgia Institutional Award (1991-1992)

Selected Publications:

  1. E Madan , R Gogna , U Pati. p53Ser15 Phosphorylation disrupts p53-RPA70 complex and induces RPA70- mediated DNA repair in hypoxia, Biochem Jour 2012(In press)
  2. E Madan, R Gogna, M Bhatt, U Pati, P Kuppusamy, A Ali Mahdi. Regulation of glucose metabolism by p53: Emerging new roles for the tumor suppressor. Oncotarget 2012 (In Press)
  3. R Gogna, E Madan, P Kuppusamy, U Pati. Chaperoning of Mt p53 by Wt p53 causes hypoxic tumor regression. Jour Biol Chem, Published on December 6, 2011 as Manuscript M111.317354
  4. R Gogna, E Madan, P Kuppusamy, U Pati. P53 core domain modifications determine apoptotic and necrotic death in cancer cells. Antioxidant & Redox Signaling, 2011 (doi: 10.1089/ars.2011.4103)
  5. R Gogna, E Madan, B Keppler, U Pati. Gallium compound GaQ3-induced Ca2+ signaling triggers p53-dependent and independent apoptosis in cancer cells, British Jour Pharmacology,2011. doi: 10.1111/j.1476-5381.2011.01780
  6. M Shrivastava, S. Vivekanandhan, U Pati, M Behari, and T K. Das. Mitochondrial Perturbance and Execution of Apoptosis in Platelet Mitochondria of Patients with Amyotrophic Lateral Sclerosis. International Journal of Neuroscience, 121, 149–158, 2011
  7. M Shrivastava, T K. Das, M Behari, U Pati, Vivekanandhan. Ultrastructural Variations in Platelets and Platelet Mitochondria: A Novel Feature in Amyotrophic Lateral Sclerosis. Ultrastruct Pathol, 35(2), 52–59, 2011
  8. A Sharma, A Ali, R Gogna, A Singh, U pati. The role of p53 amino terminus domain in displaying chaperone like function. PloS One 4 (10), 2009, 7159-
  9. S. Subhankar ,U Pati, S. Chandna, U. Stress response of a p53 homologue in the Radioresistant Sf9 insect cells, Int Jour Rad Biol 85 (3), 2009, 238-249
  10. SK Dubey, A K Sharma, U Narain, K Mishra, U Pati. Design, synthesis, and characterization of some bioactive conjugates of curcumin with glycine, glutamic acid, valine, and demethylenated piperic acid and study of their antimicrobial and anti-proliferative properties. Eur j Med Chem. 43,2008, 837-449
  11. V tripathi, A Ali, R Bhat, U Pati. CHIP chaperones wild type p53 tumor suppressor protein.Jour Biol Chem, 282, 39, 2007, 28441-454
  12. N Kapoor, A K Sharma, V Dwivedi, A Kumar, U Pati, K Mishra. Telomerase-targeted anti cancer bioactive prodrug by antisense-based approach. Cancer Lett. 248, 2007, 245-250
  13. R.Chauhan, R. Handa, Trinath P. Das, and U. Pati. Over expression of TATA-binding protein (TBP) and p53 and autoantibodies to these antigens are features of systemic sclerosis, systemic lupus erythematosus, overlap syndromes. Clin Exp Immunol .136, 2004, 574-584
  14. S. Negi, S. Singh, N. Pati, V. Handa, R. Chauhan, and U. Pati. A proximal tissue-specific and a distal negative regulatory module control apo(a) gene transcription. Biochem Jour 378, 2004, 1-9
  15. V. Handa, Mahboob-ul-Hussain, N. Pati, and U. Pati. Multiple liver-specific factors bind to a 64 bp element and activate apo(a) gene. Biphy. Biochem. Res. Comm. 292, 2002, 243-249
  16. U. Pati. Atherosclerosis and the genetic switch. Biotechnology in Health Care. Eds. T. Lazzar Mathew. Delhi, 2001
  17. U Pati and N Pati Lipoprotein(a), Atherosclerosis, and Apolipoprotein(a) Gene Polymorphism. Mol Genet Met 71, 2000, 87 – 92.
  18. U Pati and J.K.Gambhir. Apolipoprotein(a) Polymorphism and Plasma Lipoprotein(a) levels. Indian Heart Journal 52, 2000, 171-172.
  19. N. Pati, A. Rouf and U. Pati. Simultaneous mutations (A/G-418 and C/T-384) in the apo(a) promoter of individuals with low LP(a) levels, Mol. Genet. Met. 69 ,2000, 165–67.

 

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