Prof. Uttam K Pati

Dr. Uttam K Pati
Ph: +91 11 26704081
Email: ;


Ph. D. , University of New Brunswick, Canada
D. Phil, Allahabad University, Allahabad


Professor, School of Biotechnology, JNU, New Delhi.
Acting Director, Genetic Engineering Unit, JNU, New Delhi
Associate Professor, Special Centre for Biotechnology, JNU, New Delhi.
Assistant Professor of Medicine & Molecular Biology, Medical College of Georgia, Augusta, USA
Research Scientist, Yale University School of Medicine, USA
Post Doctoral Research Fellow, Massachusetts Institute of Technology, USA
Post Doctoral Research Fellow, Max-Planck Institute, Germany

Area of Interest:

Molecular chaperones & gene regulation, Molecular mechanism of hypoxia, cancer biology, Tumor suppressor protein p53, Biomarkers.


  • Medical College of Georgia Institutional Award (1991-1992)

Selected Publications:

  1. E Madan , R Gogna , U Pati. p53Ser15 Phosphorylation disrupts p53-RPA70 complex and induces RPA70- mediated DNA repair in hypoxia, Biochem Jour 2012(In press)
  2. E Madan, R Gogna, M Bhatt, U Pati, P Kuppusamy, A Ali Mahdi. Regulation of glucose metabolism by p53: Emerging new roles for the tumor suppressor. Oncotarget 2012 (In Press)
  3. R Gogna, E Madan, P Kuppusamy, U Pati. Chaperoning of Mt p53 by Wt p53 causes hypoxic tumor regression. Jour Biol Chem, Published on December 6, 2011 as Manuscript M111.317354
  4. R Gogna, E Madan, P Kuppusamy, U Pati. P53 core domain modifications determine apoptotic and necrotic death in cancer cells. Antioxidant & Redox Signaling, 2011 (doi: 10.1089/ars.2011.4103)
  5. R Gogna, E Madan, B Keppler, U Pati. Gallium compound GaQ3-induced Ca2+ signaling triggers p53-dependent and independent apoptosis in cancer cells, British Jour Pharmacology,2011. doi: 10.1111/j.1476-5381.2011.01780
  6. M Shrivastava, S. Vivekanandhan, U Pati, M Behari, and T K. Das. Mitochondrial Perturbance and Execution of Apoptosis in Platelet Mitochondria of Patients with Amyotrophic Lateral Sclerosis. International Journal of Neuroscience, 121, 149–158, 2011
  7. M Shrivastava, T K. Das, M Behari, U Pati, Vivekanandhan. Ultrastructural Variations in Platelets and Platelet Mitochondria: A Novel Feature in Amyotrophic Lateral Sclerosis. Ultrastruct Pathol, 35(2), 52–59, 2011
  8. A Sharma, A Ali, R Gogna, A Singh, U pati. The role of p53 amino terminus domain in displaying chaperone like function. PloS One 4 (10), 2009, 7159-
  9. S. Subhankar ,U Pati, S. Chandna, U. Stress response of a p53 homologue in the Radioresistant Sf9 insect cells, Int Jour Rad Biol 85 (3), 2009, 238-249
  10. SK Dubey, A K Sharma, U Narain, K Mishra, U Pati. Design, synthesis, and characterization of some bioactive conjugates of curcumin with glycine, glutamic acid, valine, and demethylenated piperic acid and study of their antimicrobial and anti-proliferative properties. Eur j Med Chem. 43,2008, 837-449
  11. V tripathi, A Ali, R Bhat, U Pati. CHIP chaperones wild type p53 tumor suppressor protein.Jour Biol Chem, 282, 39, 2007, 28441-454
  12. N Kapoor, A K Sharma, V Dwivedi, A Kumar, U Pati, K Mishra. Telomerase-targeted anti cancer bioactive prodrug by antisense-based approach. Cancer Lett. 248, 2007, 245-250
  13. R.Chauhan, R. Handa, Trinath P. Das, and U. Pati. Over expression of TATA-binding protein (TBP) and p53 and autoantibodies to these antigens are features of systemic sclerosis, systemic lupus erythematosus, overlap syndromes. Clin Exp Immunol .136, 2004, 574-584
  14. S. Negi, S. Singh, N. Pati, V. Handa, R. Chauhan, and U. Pati. A proximal tissue-specific and a distal negative regulatory module control apo(a) gene transcription. Biochem Jour 378, 2004, 1-9
  15. V. Handa, Mahboob-ul-Hussain, N. Pati, and U. Pati. Multiple liver-specific factors bind to a 64 bp element and activate apo(a) gene. Biphy. Biochem. Res. Comm. 292, 2002, 243-249
  16. U. Pati. Atherosclerosis and the genetic switch. Biotechnology in Health Care. Eds. T. Lazzar Mathew. Delhi, 2001
  17. U Pati and N Pati Lipoprotein(a), Atherosclerosis, and Apolipoprotein(a) Gene Polymorphism. Mol Genet Met 71, 2000, 87 – 92.
  18. U Pati and J.K.Gambhir. Apolipoprotein(a) Polymorphism and Plasma Lipoprotein(a) levels. Indian Heart Journal 52, 2000, 171-172.
  19. N. Pati, A. Rouf and U. Pati. Simultaneous mutations (A/G-418 and C/T-384) in the apo(a) promoter of individuals with low LP(a) levels, Mol. Genet. Met. 69 ,2000, 165–67.