Dr. Devapriya Choudhury
 

Dr. Devapriya Choudhury
Associate Professor
Ph:  +91 11 26704078
Email:  devach@mail.jnu.ac.in


Education: 

Ph.D. (X-ray Crystallography), Swedish University of Agricultural Sciences, Uppsala, Sweden.              
Ph.D.  (Molecular Biophysics), IISc, Bangalore.
M.Sc. (Biochemistry), NEHU, Shillong.

Career:

2007-
Concurrent faculty, School of Information Technology, JNU, New Delhi
2002-
Associate Professor, School of Biotechnology, JNU, New Delhi.
2001-2002
Structural Chemistry Laboratory, Astra-Zeneca, Molndahl, Sweden
1995-1997
Bioinformatics Centre, University of Pune, Pune
1991-1995
Astra Research Centre India currently known as Astra-Zeneca, Bangalore

Area of Interest:

  • Molecular Biophysics, Structural and Computational Biology

Summary of research:

Research in my laboratory is mainly concerned with understanding the effects of mutational as well as environmental perturbations on protein structures mainly through the use of molecular dynamics simulations. We are also interested in the comparative sequence analyses of specific protein families particularly those associated with bacterial pathogenesis and fungal drug resistance.

Honors/Awards:

  • University Prize for getting first class first position in B.Sc, Zoology Examination of NEHU, 1983.
  • Gold Medal for getting First Class First position in M.Sc. Biochemistry examination of NEHU, 1985.
  • Astra-Zeneca Structural Chemistry Laboratory award for the best oral presentation by a young person, at the 3rd- Annual Conference on Structural Biology held at Tallberg, Sweden

Selected Publications:

  1. M. Gaur, N. Puri, R. Manoharlal, V. Rai, G. Mukhopadhyay, D. Choudhury and  R. Prasad (2008). MFS transportome of the human pathogenic yeast Candida albicans. BMC Genomics, 9: 579.
  2. S. Banerjee, N. Mirsamadi, L. Anantharaman, M.V. Sivaram, R.B. Gupta, D. Choudhuryand R.P. Roy (2007). Modification of axial fiber contact residues impact sickle hemoglobin polymerization by perturbing a network of coupled interactions. The Protein J., 26: 445-55.
  3. J. Bouckaert,  Mackenzie, J. L. de Paz, B. Chipwaza, D. Choudhury, A.Zavialov, K. Man-nerstedt, J.Anderson, D. Pierard, L. Wyns, PH. Seeberger, S. Oscarson, H. De Greve and S.D. Knight (2006). The affinity of the FimH fimbrial adhesin is receptor-driven and quasi-independent of Escherichia coli pathotypes. Mol. Microbiol., 61: 1556-1568
  4. P. Khandelwal, D. Choudhury, A. Birah, M.K. Reddy, G.P. Gupta, and N. Banerjee (2004). Insecticidal pilin subunit from the insect pathogen Xenorhabdus nematophila. J.  Bacteriol., 186: 6465-6476.
  5. S. Rajamani, L. Anantharaman, M.V. Sivaram, N. Mirsamadi, D. Choudhury, Lohiya N.K., Gupta R.B. and Roy R.P. (2004). Linkage of interactions in sickle hemoglobin fiber assembly: Inhibitory effect emanating from mutations in the AB region of the a-chain is annulled by a mutation at its EF corner. J. Biol. Chem., 279, 20018-20027.
  6. H. Baumann, S. Ohrman, Y. Shinohara, O. Ersoy, D. Choudhury, A. Axen, U. Tedebark and E. Carredano (2003). Rational design, synthesis, and verification of affinity ligands to a protein surface cleft. Protein Science, 12: 784-793.
  7. S.D. Knight, J. Berglund and D. Choudhury (2000).Bacterial adhesins: structural studies reveal chaperone function and pilus biogenesis. Curr. Opin. Chem. Biol., 4: 653-660.
  8. E. Carredano, A .Karlsson, B . Kauppi, D. Choudhury, R.E.Parales, J.V .Parales, K. Lee, D.T.Gibson, H. Eklund and S. Ramaswamy (2000). Substrate binding site of naphthalene 1,2-dioxygenase: functional implications of indole binding. J. Mol. Biol.,296: 701-712.
  9. J. Wang, D. Choudhury, J. Chattopadhyaya and S. Eriksson (1999). Stereoisomeric selectivity of human deoxyriboriucleoside kinases. Biochemistry, 38: 16993-16999.
  10. D. Choudhury, A Thompson, V . Stojanoff, S. Langermann, J. Pinkner, S.J. Hultgren and S. D. Knight (1999). X-ray structure of the FimC-FimH chaperone-adhesin complex from uropathogenic Escherichia coli. Science, 285: 1021-1022.
  11. K. Otte, D. Choudhury , M. Charalambous, W. Engstrom and B. Rozell  (1998). A conserved struc­tural element in horse and mouse IGF2 genes binds a methylation sensitive factor). Nucleic Acids Res., 26:1605-1612.

Patent

S. J. Hultgren, E. G. Sauer, g. Waksman, K. Fuetterer, D. Choudhury,  S.D.Knight and M. Barnhart  (2006). Anti-bacterial compounds directed against pilus biogenesis, adhesion and activity; co-crystals of pilus subunits and methods of use thereof. United StatesPatent No. 7.041,465 granted on May 9, 2006.

 

 

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