Shilpee Dutt
Professor
Centre/School/Special Centre
School of Life Sciences
Room No
117
Email
shilpeedutt@mail.jnu.ac.in, drshilpeedutt@gmail.com
Personal Webpage
Qualifications
Ph.D. University of Zurich, Switzerland
M.Sc. Jamia Millia Islamia, New Delhi
B.Sc. University of Delhi
Areas of Interest/Specialization
Broad area of research of our lab is to understand the molecular basis of therapy resistance (radiation and chemotherapy) in cancer, with a specific focus on DNA repair, epigenetics, cancer stem cell biology and therapy induced senescence. To address these questions, we use patient samples, patient-derived cellular models, spheroid and tumoroid cultures and orthotopic mouse models.
Experience
- Professor at the School of Life Sciences, Jawaharlal Nehru University, New Delhi (2024- present
- Principal Investigator at ACTREC, Tata Memorial Centre, Navi Mumbai (2010-2024)
- Postdoctoral Fellow at Harvard Medical School, Boston, USA (2005-2010)
- Ph.D. from University of Zurich, Switzerland (2005)
Awards & Honours
- Janaki Ammal-National Women Bioscientist Award (young category) by Department of Biotechnology, Government of India- 2019
- President Award for the Outstanding Work in Neuro-Oncology from Indian Society for Neuro Oncology (ISNO)- 2017
- Dr Virendra Balkrishna Kamat Award from Indian Association of Cancer Research (IACR)- for our work in molecular oncology- 2016
- Swiss National Science Foundation Postdoctoral Fellowship- 2005
- Best oral presentation award, University of Zurich- 2004
- Travel award for a presentation at the Society for Neuroscience USA- 2004
- Best oral presentation award, The Connective Tissue Society meeting, Ulm, Germany- 2003
- CSIR JRFship and UGC JRFship- 1998
- First Position in Zoology and Botany in B.Sc., University of Delhi- 1996
International Collaboration/Consultancy
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Best Peer Reviewed Publications
For complete list of publications please click PubMed
Few Selected Publication
- DNA-PKcs mediated transcriptional regulation of Top2B drives chemo resistance in acute myeloid leukemia. Saket V Mishra, Archisman Banerjee, Debashmita Sarkar, Vishnu Thangarathnam, Bhausab Bagal, Sayed K Hasan, Shilpee Dutt*. Journal of Cell Science. 2024 Jan 19:jcs.261931.
doi: 10.1242/jcs.261931 - Substrate stiffness regulates the recurrent glioblastoma cell morphology and aggressiveness. Anagha Acharekar, Ketaki Bachal, Pallavi Shirke, Rahul Thorat, Archisman Banerjee, Nilesh Gardi, Abhijit Majumder, Shilpee Dutt*. Matrix Biology. 2023 Jan;115:107-127.
https://doi.org/10.1016/j.matbio.2022.12.002 - DUSP6 regulates radio-sensitivity in glioblastoma by modulating the recruitment of p-DNAPKcs at DNA double-strand breaks. Jyothi Nair, Safiulla Basha Syed, Tejashree Mahaddalkar, Madhura Ketkar, Rahul Thorat, Jayant Sastri Goda, Shilpee Dutt*. Journal of Cell Science. 2021.
https://doi.org/10.1242/jcs.259520 - Nuclear localization of p65 reverses therapy induced senescence. Sameer Salunkhe, Saket V. Mishra, Jyothi Nair, Sanket Shah, Nilesh Gardi, Rahul Thorat, Debashmita Sarkar, Jacinth Rajendra, Ekjot Kaur, Shilpee Dutt*. Journal of Cell Science. 2021 Mar 26;134(6):jcs253203.
doi: 10.1242/jcs.253203 - Sustained Inhibition of PARP-1 Activity Delays Glioblastoma Recurrence by Enhancing Radiation-Induced Senescence. AtanuGhorai,TejashreeMahaddalkar, RahulThorat, Shilpee Dutt*. Cancer Letters. 2020 Jul 6;S0304-3835(20)30353-0.
doi: 10.1016/j.canlet.2020.06.023 - Inhibition of SETMAR-H3K36ME2-NHEJ repair axis in residual disease cells prevent glioblastoma recurrence. Kaur E, Nair J, Ghorai A, Mishra SV, Achareker A, Ketkar M, Sarkar D, Salunkhe S, Rajendra J, Gardi N, Desai S, Iyer P, Thorat R, Dutt A, Moiyadi A, Shilpee Dutt*. Neuro Oncol. 2020 May 27:noaa128.
doi: 10.1093/neuonc/noaa128 - CytoPred: 7-gene pair metric for AML cytogenetic risk prediction. Sameer Salunkhe, Chandran N, Prateek Chandrani, Amit Dutt, Shilpee Dutt*. Briefings in Bioinformatics. 2018 Oct 30
https://doi.org/10.1093/bib/bby100 - Inhibition of novel GCN5-ATM axis restricts the onset of acquired drug resistance in leukemia. Salunkhe S, Mishra SV, Nair J, Ghosh S, Choudhary N, Kaur E, Shah S, Patkar K, Anand D, Khattry N, Hasan SK, Dutt S*. Int J Cancer. 2018 May 15;142(10):2175-2185.
https://doi.org/10.1002/ijc.31242 - Enhanced proteasomal activity is essential for long term survival and recurrence of innately radiation resistant residual glioblastoma cells. Rajendra J, Datta KK, Ud Din Farooqee SB, Thorat R, Kumar K, Gardi N, Kaur E, Nair J, Salunkhe S, Patkar K, Desai S, Goda JS, Moiyadi A, Dutt A, Venkatraman P, Gowda H, Dutt S*. Oncotarget. 2018 Jun 12;9(45):27667-27681.
https://doi.org/10.18632/oncotarget.25351 - Radiation-induced homotypic cell fusions of innately resistant glioblastoma cells mediate their sustained survival and recurrence. Kaur E, Rajendra J, Jadhav S, Shridhar E, Goda JS, Moiyadi A, Dutt S*. Carcinogenesis. 2015 Jun;36(6):685-95.
https://doi.org/10.1093/carcin/bgv050
Recent Peer Reviewed Journals/Books
Book Chapters
- Emerging drug delivery systems to alter tumor immunosuppressive microenvironment: Overcoming the challenges in immunotherapy for glioblastoma. P. Soma Yasaswi, Harsh P. Nijhawan, Bala Prabhakar, Shilpee Dutt, Khushwant S. Yadav. Progress in Molecular Biology and Translational Science. Academic Press, 2024, ISSN 1877-1173,
https://doi.org/10.1016/bs.pmbts.2024.04.006 - Role of cancer stem cells in maintenance of cancer heterogeneity in brain tumors. Bhawna Singh and Shilpee Dutt*. Cancer stem cells and signaling pathways. Academic Press.
https://doi.org/10.1016/B978-0-443-13212-4.00008-8 - Ketkar, M., Dutt, S. (2022). Epigenetic Regulation Towards Acquired Drug Resistance in Cancer. In: Kundu, T.K., Das, C. (eds) Metabolism and Epigenetic Regulation: Implications in Cancer. Subcellular Biochemistry, vol 100. Springer, Cham.
https://link.springer.com/chapter/10.1007/978-3-031-07634-3_14 - ROS Signaling in Brain Tumor. Debashmita Sarkar, Shilpee Dutt*. (2022) In: Chakraborti S. (eds) Handbook of Oxidative Stress in Cancer: Therapeutic Aspects. Springer, Singapore.
https://doi.org/10.1007/978-981-16-1247-3_242-1 - Chromatin dynamics orchestrates DNA repair mechanisms in glioblastoma. Tejashree Mahaddalkar#, Bhwana Singh#, Shilpee Dutt*. # equal contribution. International Journal of Neurooncology. 4(2):p 38-45, Jul–Dec 2021.
DOI: 10.4103/IJNO.IJNO_20_21
Patents (if any)
Patent Number- 408307
Patentee - 1. Indian Institute of Technology Bombay 2. Tata Memorial Centre
Inventors- Benerjee Rinti, Sandbhor Puja Sahashikant, Goda Jayant Shastri, Mohanty Bhabhani Shankar, Chaudhari Pradip Ramdas, Shilpee Dutt
Invention – NANOPARTICLES INCORPORATED SELF-GELLING COMPOSITION AS DRUG DELIVERY SYSTEM