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Manoj Munde

Manoj Munde
Manoj Munde
Assistant Professor
Centre/School/Special Centre
School of Physical Sciences
Off. Phone
011-26738933
Residence
09910052147
Email
mmunde[at]mail[dot]jnu[dot]ac[dot]in, mundemanoj[at]gmail[dot]com
Personal Webpage
Biophysical Chemistry Lab
Personal files
munde_cv.pdf
Qualifications

Ph.D. (2006, IIT Bombay)

Areas of Interest/Specialization

Biophysical Chemistry, Thermodynamics and kinetics, Biomolecular complexes of proteins, DNAs and Drugs

Experience

Aug 2014-Present Assistant Professor, School of Physical Sciences, Jawaharlal Nehru University, New Delhi

Sept 2013-Aug 2014 Assistant Professor, Central University of Rajasthan, Bandarsindri, Ajmer, Rajasthan

Oct 2010-Aug 2013 Research Associate, Georgia State University, Atlanta, USA

Jan 2006-Sept 2010 Postdoctoral Associate, Georgia State University, Atlanta, USA 

Awards & Honours

Selected as UGC Assistant Professor under UGC Faculty Recharge Program (2013)

Awarded NIH postdoctoral fellowship (2006) 

Awarded Teaching Assistantship at IIT Bombay (2001) 

Best Peer Reviewed Publications

* An Unusual Monomer Recognition of Guanine Containing Mixed Sequence DNA by a Dithiophene Heterocyclic Diamidine. Munde M, Kumar A, Peixoto P, Depauw S, Ismail MA, Farahat AA, Paul A, Say MV, David-Cordonnier MH, Boykin DW, Wilson WD. Biochemistry (2014) 53, 1218-27

* Structure-dependent inhibition of the ETS-family transcription factor PU.1 by novel heterocyclic diamidines. Munde M, Wang S, Kumar A, Stephens CE, Abdelbasset A. Farahat, Boykin DW, Wilson WD, Poon GM. Nucleic Acid Research (2014) 42, 1379-90

* DNA minor groove induced dimerization of heterocyclic cations: compound structure, binding affinity, and specificity for a TTAA site. Munde, M., Kumar, A., Nhili, R., Depauw, S., David-Cordonnier, M. H., Ismail, M. A., Stephens, C. E., Farahat, A. A., Batista-Parra, A., Boykin, D. W., and Wilson, W. D., J Mol Biol (2010) 402, 847-864.

* Induced fit conformational changes of a reversed amidine heterocycle:optimized interactions in a DNA minor groove complex. Munde, M., Lee, M., Neidle, S., Arafa, R., Boykin, D. W., Liu, Y., Bailly, C., and Wilson, W. D., J Am Chem Soc (2007) 129, 5688-5698.

* Design of DNA minor groove binding diamidines that recognize GC base pair sequences: a dimeric-hinge interaction motif. Munde, M., Ismail, M. A., Arafa, R., Peixoto, P., Collar, C. J., Liu, Y., Hu, L., David-Cordonnier, M. H., Lansiaux, A., Bailly, C., Boykin, D. W., and Wilson, W. D., J Am Chem Soc (2007) 129, 13732-13743. 

Recent Peer Reviewed Journals/Books

* Mechanistic Heterogeneity in Site Recognition by the Structurally Homologous DNA-Binding Domains of the ETS-Family Transcription Factors Ets-1 and PU.1Sang S, Linde MH, Carvalho V, Munde M, Wilson WD, Poon G, Journal of Biological Chemistry (2014) 289, 21605-16.

* Probing the electrostatics and pharmacologic modulation of sequence-specific binding by the DNA-binding domain of the ETS-family transcription factor PU.1: a binding affinity and kinetics investigation. Munde M, Poon GM, Wilson WD., J Mol Biol. (2013) 425, 1455-59.