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Karunakar Kar

Karunakar Kar
Karunakar Kar
Associate Professor
Centre/School/Special Centre
School of Life Sciences
Off. Phone
4517
Email
kkar[at]mail[dot]jnu[dot]ac[dot]in, karunakarkar[at]gmail[dot]com
Personal Webpage
google.site
Qualifications
Ph.D.
Areas of Interest/Specialization

BIOPHYSICAL  AND BIOMATERIALS RESEARCH LABORATORY

1.In-born Metabolic Diseases 

2.Protein Biophysics,

3.Amyloids and Collagen associated diseases. 

4.Rationally Engineered Biomaterials and Nanoparticles.

Experience

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Awards & Honours

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International Collaboration/Consultancy

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Best Peer Reviewed Publications

  1. Prajapati. K.P., Mittal S., Ansari, M., Mahato, O.P., Mishra, N., Tiku, A.B., Anand, B.G., Kar, K. Structural conversion of Serotonin into amyloid-like nanoassembly conceptualizes an unexplored neurotoxicity risk, ACS Nano 2024, 18, 50, 34044–34062 (LINK)
  2. Mittal, S., Prajapati, K.P., Joshi K., Ansari M., Mohato O.P., Anand, B.G., Kar, K. Cu(II) specifically disintegrates amyloid nanostructures via direct intercalation into cross-b architecture.   Nano Letters 2024, 24, 32, 9784–9792 [Front Cover Article] (LINK)
  3. Prajapati, K. P., Mittal, S., Ansari, M., Mohato, O. P., Bharti, S., Ahlawat, S., Tiku, A. B., Anand, B. G., Kar, K. Pleiotropic nanostructures built from L-histidine show biologically relevant multi-catalytic activities. ACS Applied Materials and Interfaces:  2024, 16, 18268–18284.(LINK)
  4. Anand B.G., Prajapati K.P., Dubey K., Ahamad N, Shekhawat D.S., Rath P.C., Joseph G.K., Kar K. Self-Assembly of Artificial Sweetener Aspartame Yields Amyloid-Like Cytotoxic Nanostructures. ACS Nano. (2019); 13(5): 6033-6049. (LINK)
  5. Prajapati. K.P, Ansari M., Mittal, S., Anand, B.G., Kar, K. Initiation of Brain Extract Fibrillation and Effective Cellular Internalization of Tryptophan fibrils unveils its neurotoxicity threat. ACS Chemical Neuroscience, 2023, 14, 24, 4274-4281 [Front Cover Article] (LINK)
  6. Ansari M., Prajapati, K.P., Anand, B.G., Chaudhuri, P., Mittal, S., Kar, K. Construction of  Chemoreactive Heterogeneous Nanofibers Through Strategic Co-assembly of Different Proteins Materials Today Nano 2023, 22, 100317 (LINK)
  7. Anand B.G., Prajapati, K.P., Shekhawat, D.S., Kar, K. Tyrosine generated nanostructures initiate amyloid cross-seeding in proteins leading to lethal aggregation trap. Biochemistry. (2018) 57 (35), 5202-5209 (LINK)
  8. Dubey, K., Anand, B.G., Shekhawat, D.S. and Kar, K. Eugenol prevents amyloid formation of proteins and inhibits amyloid-induced hemolysis. Scientific Reports (2017) 7: 40744
  9. Kar, K., Jayaraman, M., Sahoo, B., Kodali, R., Wetzel, R., Critical nucleus size for disease-related polyglutamine aggregation is repeat length dependent. Nature Structural & Molecular Biology, (2011) 18: 328-336 (LINK)
  10. Misra, P., Kodali, R., Chemuru, S., Kar, K., Wetzel, R. Rapid alfa-oligomer formation mediated by the Abeta C-terminus initiates an amyloid assembly pathway. Nature Communication (2016) 7:12419
  11. Kar, K., Amin, P., Bryan, M.A., Persikov, A.V., Mohs, A., Wang, Y.H., Brodsky, B., Self- association of collagen triple helical peptides into higher order structures. Journal of Biological Chemistry (2006) 281:33283-33290. 
  12. Kar, K., Hoop, C., Baker, M.A., Lengyel, G., Kodali, R., van der Wel, P., Horne, S., Wetzel, R., Backbone engineering within a latent ß-hairpin structure to design inhibitors of polyglutamine amyloid formation. Journal of Molecular Biology (2016) 429(2):308-323. 
Recent Peer Reviewed Journals/Books
  1. Anand, B.G., Prajapati. K.P., Ansari, M., Yadav, D. K., Temgire, M., Kar, K.* The genesis of neurotoxic hybrid nanofibers from the co-assembly of aromatic amino acids. ACS Applied Materials & Interfaces. 2021; 13, 31, 36722–36736
  2. Prajapati. K.P., Anand, B.G., Temgire, M., Tiku, A.B., Kar, K.* Amyloid-mimicking toxic nanofibers generated via self-assembly of dopamine Nanoscale 2022, 14, 8649 – 8662
  3. Ansari M., Prajapati, K.P., Mittal S., Anand, B.G,, Mishra, N., Anand, B., Kar, K.* Sequence Independent Rapid Co-aggregation of Proteins: Possible Role of Conformational Complementarity: Biochemistry  2024, 63, 2977–2989 (Front Cover Article)
  4. Anand, B.G., Dubey, K., Singh, D.S, Prajapati, K.P.,  Kar, K.*, Strategically desinged anitifibrotic gold nanoparticles to prevent collagen fibrill formation, Langmuir (2017) 33: 13252-13261
  5. Anand, B.G., Dubey, K., Singh, D., Kar, K.*, Capsaicin coated silver nanoparticles inhibit amyloid fibril formation of serum albumin, Biochemistry (2016) 55: 3345-3348
  6. Dubey, K., Bibin G. Anand, Temgire, M., Kar, K*. Evidence of coaggregation globular proteins during amyloid formation. Biochemistry, (2014) 53:8001-8004
  7. Hoop, C.L., Lin, H.K., Kar, K., Magyarfalvi, G., Lamley, J.M., Boatz, J.C., Lewandowski, J.R., Wetzel, R., van der Wel, P.C. Huntingtin exon 1 fibrils feature an interdigitated ß-hairpin–based polyglutamine core. Proceedings of the National Academy of Sciences (2016) 113:1546-1551
Patents (if any)

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