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Shilpee Dutt

Shilpee Dutt

Shilpee Dutt
Shilpee Dutt
Professor
Centre/School/Special Centre
School of Life Sciences
Room No
117
Off. Phone
011-26704516
Email
shilpeedutt@jnu.ac.in, drshilpeedutt@gmail.com
Personal Webpage
https://www.shilpeedutt-lab.com/
Qualifications

Ph.D. University of Zurich, Switzerland
M.Sc. Jamia Millia Islamia, New Delhi
B.Sc. University of Delhi

Areas of Interest/Specialization

The broad area of research of our lab is to understand the molecular basis of therapy resistance (radiation and chemotherapy) in cancer, with a focus on DNA repair, epigenetics, cancer stem cell biology, and therapy-induced senescence. We use patient samples, patient-derived cellular models, spheroid and tumoroid cultures, and orthotopic mouse models to address these questions.

Experience
  • Professor at the School of Life Sciences, Jawaharlal Nehru University, New Delhi (2024- present)
  • Principal Investigator at ACTREC, Tata Memorial Centre, Navi Mumbai (2010-2024)
  • Postdoctoral Fellow at Harvard Medical School, Boston, USA (2005-2010)
  • Ph.D. from University of Zurich, Switzerland (2005)
Awards & Honours
  • Janaki Ammal-National Women Bioscientist Award (young category) by Department of Biotechnology, Government of India- 2019
  • President Award for the Outstanding Work in Neuro-Oncology from Indian Society for Neuro Oncology (ISNO)- 2017
  • Dr Virendra Balkrishna Kamat Award from Indian Association of Cancer Research (IACR)- for our work in molecular oncology- 2016
  • Swiss National Science Foundation Postdoctoral Fellowship- 2005
  • Best oral presentation award, University of Zurich- 2004
  • Travel award for a presentation at the Society for Neuroscience USA- 2004
  • Best oral presentation award, The Connective Tissue Society meeting, Ulm, Germany- 2003
  • CSIR JRFship and UGC JRFship- 1998
  • First Position in Zoology and Botany in B.Sc., University of Delhi- 1996 
Best Peer Reviewed Publications

For complete list of publications please click PubMed

Few Selected Publication

  1. Aurora Kinase A and B inhibition abrogates ‘Neosis’, a non-mitotic cell division of GBM residual cells and prevents GBM recurrence. Tejashree Mahaddalkar, Archisman Banerjee, Madhura Ketkar, Rahul Thorat, Nilesh Gardi, Shilpee Dutt*. Oncogene. 07 April 2025 https://doi.org/10.1038/s41388-025-03372-6
  2. Bi-phasic DNA damage and non-canonical replication stress response govern radiation-induced senescence in Glioblastoma. Atanu Ghorai, Bhawna Singh, Shilpee Dutt*. Journal of Cell Sciences. jcs.261844. https://doi.org/10.1242/jcs.261844
  3. PARylation of GCN5 by PARP1 mediates its recruitment to DSBs and facilitates both HR and NHEJ Repair. Debashmita Sarkar, Amartya Chakraborty, Shaina Mandi, Shilpee Dutt*. Cellular and Molecular Life Sciences, 81, 446 (2024). https://doi.org/10.1007/s00018-024-05469-9
  4. Inhibition of PERK mediated UPR acts as a switch for reversal of residual senescence and as senolytic therapy in glioblastoma. Madhura Ketkar, Sanket Desai, Pranav Rana, Rahul Thorat, Sridhar Epari, Amit Dutt, Shilpee Dutt*. Neuro-Oncology, 18 July 2024, noae 134 https://doi.org/10.1093/neuonc/noae134
  5. DNA-PKcs mediated transcriptional regulation of Top2B drives chemo resistance in acute myeloid leukemia. Saket V Mishra, Archisman Banerjee, Debashmita Sarkar, Vishnu Thangarathnam, Bhausab Bagal, Sayed K Hasan, Shilpee Dutt*. Journal of Cell Science. 2024 Jan 19:jcs.261931. doi: 10.1242/jcs.261931
  6. Substrate stiffness regulates the recurrent glioblastoma cell morphology and aggressiveness. Anagha Acharekar, Ketaki Bachal, Pallavi Shirke, Rahul Thorat, Archisman Banerjee, Nilesh Gardi, Abhijit Majumder, Shilpee Dutt*. Matrix Biology. 2023 Jan;115:107-127. https://doi.org/10.1016/j.matbio.2022.12.002
  7. DUSP6 regulates radio-sensitivity in glioblastoma by modulating the recruitment of p-DNAPKcs at DNA double-strand breaks. Jyothi Nair, Safiulla Basha Syed, Tejashree Mahaddalkar, Madhura Ketkar, Rahul Thorat, Jayant Sastri Goda, Shilpee Dutt*. Journal of Cell Science. 2021. https://doi.org/10.1242/jcs.259520
  8. Nuclear localization of p65 reverses therapy induced senescence. Sameer Salunkhe, Saket V. Mishra, Jyothi Nair, Sanket Shah, Nilesh Gardi, Rahul Thorat, Debashmita Sarkar, Jacinth Rajendra, Ekjot Kaur, Shilpee Dutt*. Journal of Cell Science. 2021 Mar 26;134(6):jcs253203. doi: 10.1242/jcs.253203
  9. Sustained Inhibition of PARP-1 Activity Delays Glioblastoma Recurrence by Enhancing Radiation-Induced Senescence. AtanuGhorai,TejashreeMahaddalkar, RahulThorat, Shilpee Dutt*. Cancer Letters. 2020 Jul 6;S0304-3835(20)30353-0. doi: 10.1016/j.canlet.2020.06.023
  10. Inhibition of SETMAR-H3K36ME2-NHEJ repair axis in residual disease cells prevent glioblastoma recurrence. Kaur E, Nair J, Ghorai A, Mishra SV, Achareker A, Ketkar M, Sarkar D, Salunkhe S, Rajendra J, Gardi N, Desai S, Iyer P, Thorat R, Dutt A, Moiyadi A, Shilpee Dutt*. Neuro Oncol. 2020 May 27:noaa128. doi: 10.1093/neuonc/noaa128
Recent Peer Reviewed Journals/Books

Book Chapters

  1. Emerging drug delivery systems to alter tumor immunosuppressive microenvironment: Overcoming the challenges in immunotherapy for glioblastoma. P. Soma Yasaswi, Harsh P. Nijhawan, Bala Prabhakar, Shilpee Dutt, Khushwant S. Yadav. Progress in Molecular Biology and Translational Science. Academic Press, 2024, ISSN 1877-1173,
    https://doi.org/10.1016/bs.pmbts.2024.04.006
  2. Role of cancer stem cells in maintenance of cancer heterogeneity in brain tumors. Bhawna Singh and Shilpee Dutt*. Cancer stem cells and signaling pathways. Academic Press.
    https://doi.org/10.1016/B978-0-443-13212-4.00008-8
  3. Ketkar, M., Dutt, S. (2022). Epigenetic Regulation Towards Acquired Drug Resistance in Cancer. In: Kundu, T.K., Das, C. (eds) Metabolism and Epigenetic Regulation: Implications in Cancer. Subcellular Biochemistry, vol 100. Springer, Cham.
    https://link.springer.com/chapter/10.1007/978-3-031-07634-3_14
  4. ROS Signaling in Brain Tumor. Debashmita Sarkar, Shilpee Dutt*. (2022) In: Chakraborti S. (eds) Handbook of Oxidative Stress in Cancer: Therapeutic Aspects. Springer, Singapore.
    https://doi.org/10.1007/978-981-16-1247-3_242-1
  5. Chromatin dynamics orchestrates DNA repair mechanisms in glioblastoma. Tejashree Mahaddalkar#, Bhwana Singh#, Shilpee Dutt*. # equal contribution. International Journal of Neurooncology. 4(2):p 38-45, Jul–Dec 2021.
    DOI: 10.4103/IJNO.IJNO_20_21
Patents (if any)

Patent Number- 408307
Patentee - 1. Indian Institute of Technology Bombay 2. Tata Memorial Centre
Inventors- Benerjee Rinti, Sandbhor Puja Sahashikant, Goda Jayant Shastri, Mohanty Bhabhani Shankar, Chaudhari Pradip Ramdas, Shilpee Dutt
Invention – NANOPARTICLES INCORPORATED SELF-GELLING COMPOSITION AS DRUG DELIVERY SYSTEM

A warm welcome to the modified and updated website of the Centre for East Asian Studies. The East Asian region has been at the forefront of several path-breaking changes since 1970s beginning with the redefining the development architecture with its State-led development model besides emerging as a major region in the global politics and a key hub of the sophisticated technologies. The Centre is one of the thirteen Centres of the School of International Studies, Jawaharlal Nehru University, New Delhi that provides a holistic understanding of the region.

Initially, established as a Centre for Chinese and Japanese Studies, it subsequently grew to include Korean Studies as well. At present there are eight faculty members in the Centre. Several distinguished faculty who have now retired include the late Prof. Gargi Dutt, Prof. P.A.N. Murthy, Prof. G.P. Deshpande, Dr. Nranarayan Das, Prof. R.R. Krishnan and Prof. K.V. Kesavan. Besides, Dr. Madhu Bhalla served at the Centre in Chinese Studies Programme during 1994-2006. In addition, Ms. Kamlesh Jain and Dr. M. M. Kunju served the Centre as the Documentation Officers in Chinese and Japanese Studies respectively.

The academic curriculum covers both modern and contemporary facets of East Asia as each scholar specializes in an area of his/her interest in the region. The integrated course involves two semesters of classes at the M. Phil programme and a dissertation for the M. Phil and a thesis for Ph. D programme respectively. The central objective is to impart an interdisciplinary knowledge and understanding of history, foreign policy, government and politics, society and culture and political economy of the respective areas. Students can explore new and emerging themes such as East Asian regionalism, the evolving East Asian Community, the rise of China, resurgence of Japan and the prospects for reunification of the Korean peninsula. Additionally, the Centre lays great emphasis on the building of language skills. The background of scholars includes mostly from the social science disciplines; History, Political Science, Economics, Sociology, International Relations and language.

Several students of the centre have been recipients of prestigious research fellowships awarded by Japan Foundation, Mombusho (Ministry of Education, Government of Japan), Saburo Okita Memorial Fellowship, Nippon Foundation, Korea Foundation, Nehru Memorial Fellowship, and Fellowship from the Chinese and Taiwanese Governments. Besides, students from Japan receive fellowship from the Indian Council of Cultural Relations.